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comparative pharmacokinetics of florfenicol uses

  • Comparative pharmacokinetics of florfenicol in healthy and ...

    Pasteurella multocida is the causative agent of fowl cholera, and florfenicol (FF) has potent antibacterial activity against P. multocida and is widely used in the poultry industry. In this study, we established a P. multocida infection model in ducks and studied the pharmacokinetics of FF in serum and lung tissues after oral administration of 30 mg/kg bodyweight.

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  • Comparative pharmacokinetics of florfenicol in healthy and ...

    2019-3-25 · Pasteurella multocida is the causative agent of fowl cholera, and florfenicol (FF ) has potent antibacterial activity against P. multocida and is widely used in the poultry industry. In this study, we established a P. multocida infection model in ducks and studied the pharmacokinetics of FF in serum and lung tissues after oral administration of 30 mg/kg bodyweight.

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  • Comparative pharmacokinetics of florfenicol granule and ...

    The pigs in group B were also orally administrated with single dose of florfenicol granule at 30 mg/kg. Comparative study on the pharmacokinetics pharmacokinetics Subject Category: Miscellaneous see more details of florfenicol powder and florfenicol granule was carried out. Plasma concentration of florfenicol was determined by HPLC.

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  • Comparative Pharmacokinetics of Tylosin or Florfenicol ...

    The quantitation limit (QL) of florfenicol was 0.1 μg/m l, the inter-day and intra-day precision (CV%) were both beow 10%. The quantitation limit (QL) of tylosin was 0.05 μg/mL. The pharmacokinetic characteristics after i.m. doses were fitted by a one compartment open model.

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  • Comparative muscle irritation and pharmacokinetics of ...

    Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs. Florfenicol (FF) is a novel animal-specific amidohydrin broad-spectrum antibiotic.

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  • FLORFENICOL PHARMACODYNAMIC, PHARMACOKINETICS

    2006-6-16 · By comparing the pharmacokinetic parameters from fasted and fedpigs after oral administration of florfenicol, it is suggested that both bioavailabili-ties were similar and the half-lives of elimination were rather long. The high Cmaxwas reached in 1 h and 2 h in fasted and fed pigs, respectively. The results showedthat feeding has little impact on absorbtion of florfenicol …

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  • Comparative Plasma Pharmacokinetics and Tolerance of ...

    The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats. The concentration of florfenicol in plasma was determined using a microbiological assay. Pharmacokinetic analysis was performed using a two-compartment ...

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  • COMPARATIVE ALLOMETRIC ANALYSIS OF

    2006-7-5 · Comparative allometric analysis of pharmacokinetics of florfenicol and tiamphenicol 116 BJVM, 9, No 2 (Jianzhong et al., 2003). Florfenicol ex-hibits a broad antibacterial spectrum and a strong antibacterial activity, similar to those of chloramphenicol. At the same time, its toxicological profile is more fa-

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  • Comparative single-dose pharmacokinetics of orally ...

    Comparative single-dose pharmacokinetics of orally administered florfenicol in rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) at health and experimental infection with Streptococcus iniae or Lactococcus garvieae. Shiry N(1), Shomali T(2), Soltanian S(1), Akhlaghi M(1).

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  • Comparative muscle irritation and pharmacokinetics of ...

    2019-11-13 · A comparison was conducted between FF and FF-HP-β-CD freeze-dried powder injection of their muscle irritation and the pharmacokinetics. The drug loading and saturated solubility of FF-HP-β-CD at...

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  • Comparative pharmacokinetics of two florfenicol ...

    2019-10-24 · OBJECTIVE To compare the pharmacokinetics of 2 commercial florfenicol formulations following IM and SC administration to sheep.. ANIMALS 16 healthy adult mixed-breed sheep.. PROCEDURES In a crossover study, sheep were randomly assigned to receive florfenicol formulation A or B at a single dose of 20 mg/kg, IM, or 40 mg/kg, SC. After a 2-week washout …

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  • Comparative pharmacokinetics of florfenicol in the chicken ...

    2009-1-1 · Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs. Fan G, Zhang L, Shen Y, Shu G, Yuan Z, Lin J, Zhang W, Peng G, Zhong Z, Yin L, Fu H

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  • Comparative pharmacokinetics of florfenicol in the chicken ...

    2009-2-19 · 1. The pharmacokinetics of florfenicol were investigated in chickens (n = 20), pigeons (n = 30) and quails (n = 60) following intravenous (i.v.) and intramuscular (i.m.) administration of 30 mg/kg body weight.The concentration of florfenicol was measured using high performance liquid chromatography with ultraviolet detection.

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  • Comparative pharmacokinetics of two florfenicol ...

    OBJECTIVE To compare the pharmacokinetics of 2 commercial florfenicol formulations following IM and SC administration to sheep. ANIMALS 16 healthy adult mixed-breed sheep. PROCEDURES In a crossover study, sheep were randomly assigned to receive florfenicol formulation A or B at a single dose of 20 mg/kg, IM, or 40 mg/kg, SC.

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  • Comparative Pharmacokinetics of Tylosin or Florfenicol ...

    Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs Mi-Hee KIM , Elias GEBRU , Zhi-Qiang CHANG , Jae-Young CHOI , Mi-Hyun HWANG , Eun-Hee KANG , Jong-Hwan LIM , Hyo-In YUN , Seung-Chun PARK

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  • Comparative plasma pharmacokinetics and tolerance of ...

    Florfenicol, a monofluorinated analogue of thiamphenicol, has a broad antibacterial spectrum. The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats.

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  • Comparative muscle irritation and pharmacokinetics of ...

    Florfenicol (FF) is a novel animal-specific amidohydrin broad-spectrum antibiotic. However, its aqueous solubility is extremely poor, far below the effective dose required for veterinary clinic. Thus, FF is often used in large doses, which significantly limits its preparation and application. To overcome these shortcomings, the FF-hydroxypropyl-β-cyclodextrin (FF-HP-β-CD) inclusion …

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  • Pharmacokinetics of florfenicol and thiamphenicol in ducks ...

    2018-9-21 · Comparative pharmacokinetics of florfenicol in healthy and Pasteurella multocida-infected Gaoyou ducks. Lan W, Xiao X, Jiang Y, Jiang L, Zhao X, Yu Z, Zhu B, Li C, Bian L, Wang Z. J Vet Pharmacol Ther, 42(3):355-360, 25 Mar 2019 Cited by: 1 article | PMID: 30912167

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  • Florfenicol | C12H14Cl2FNO4S - PubChem

    2017-4-21 · Pharmacokinetics of Florfenicol in Ducks Infected with Riemerella anatipestifer After Intramuscular Administration[J].Scientia Agricultura Sinica, …

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  • Comparative pharmacokinetics of two florfenicol ...

    2019-10-24 · OBJECTIVE To compare the pharmacokinetics of 2 commercial florfenicol formulations following IM and SC administration to sheep.. ANIMALS 16 healthy adult mixed-breed sheep.. PROCEDURES In a crossover study, sheep were randomly assigned to receive florfenicol formulation A or B at a single dose of 20 mg/kg, IM, or 40 mg/kg, SC. After a 2-week washout …

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  • Comparative plasma pharmacokinetics and tolerance of ...

    Florfenicol, a monofluorinated analogue of thiamphenicol, has a broad antibacterial spectrum. The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats.

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  • Comparative Pharmacokinetics of Tylosin or Florfenicol after

    Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs Mi-Hee KIM , Elias GEBRU , Zhi-Qiang CHANG , Jae-Young CHOI , Mi-Hyun HWANG , Eun-Hee KANG , Jong-Hwan LIM , Hyo-In YUN , Seung-Chun PARK

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  • [PDF] Pharmacokinetics and Bioequivalence of Florfenicol ...

    A pharmacokinetic and bioequivalence evaluation of two florfenicol oral solutions was carried out in 28 healthy broiler chickens after oral administration of a single dose of 20 mg/kg bw, according to a randomized, parallel experimental design. The two formulations were: Flonicol® (Mobedco, Jordan) as a test product and Veterin®10% (Centrovet, Chile) as a reference product.

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  • [PDF] Pharmacokinetics of florfenicol following ...

    Florfenicol is a synthetic broad-spectrum antibiotic used to treat infectious diseases in veterinary medicine. Limited information is available on the pharmacokinetics and bioavailability of florfenicol in dogs. This study was conducted in six healthy dogs to determine the bioavailability and pharmacokinetics of florfenicol following a single intravenous ( i.v.) and intramuscular ( i.m.) dose …

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  • [PDF] Pharmacokinetics of florfenicol in cod Gadus morhua ...

    The pharmacokinetic profile of the antibacterial agent florfenicol was studied in plasma after intravenous (i.v.) injection and in plasma, muscle and liver following oral (p.o.) administration to cod Gadus morhua, held in seawater at 8 degrees C and weighing 100 to 200 g. Following i.v. injection, the plasma drug concentration-time profile showed 2 distinct phases.

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  • Florfenicol: Uses, Interactions, Mechanism of Action ...

    2016-2-25 · Park BK, Lim JH, Kim MS, Hwang YH, Yun HI: Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in dogs. Res Vet Sci. 2008 Feb;84(1):85-9. Epub 2007 Jun 13. Blickwede M, Valentin-Weigand P, Schwarz S: Subinhibitory concentrations of florfenicol enhance the adherence of florfenicol-susceptible and florfenicol-resistant ...

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  • Clinical efficacy of florfenicol administered in the ...

    2019-4-15 · an important influence of the photoperiod on the pharmacokinetics of florfenicol as well as the clinical outcome in an infection model. It can be advised that the photoperiod should be B20 h to have sufficient drug intake. Nevertheless, there was no effect between fed and fasted turkeys for both the pharmacokinetics and the clinical outcome ...

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  • Frontiers | Comparative Pharmacokinetics of Meloxicam ...

    2021-4-15 · al. Comparative pharmacokinetics and preliminary pharmacodynamics evaluation of Piscidin 1 against PRV and ... Zhixin Lei, et al. Resistant cutoff values and optimal scheme establishments for florfenicol against Escherichia coli with PK-PD modeling ...

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  • Comparative Pharmacokinetics of Tylosin or Florfenicol after

    Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs Mi-Hee KIM , Elias GEBRU , Zhi-Qiang CHANG , Jae-Young CHOI , Mi-Hyun HWANG , Eun-Hee KANG , Jong-Hwan LIM , Hyo-In YUN , Seung-Chun PARK

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  • Comparative Plasma Pharmacokinetics and Tolerance of ...

    2004-10-8 · Read 'Comparative Plasma Pharmacokinetics and Tolerance of Florfenicol following Intramuscular and Intravenous Administration to Camels, Sheep and Goats, Veterinary Research Communications' on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

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  • Comparative pharmacokinetics of oxytetracycline in tilapia ...

    2018-10-1 · Comparative pharmacokinetics of oxytetracycline in tilapia (Oreochromis spp.) maintained at three different salinities. ... Feng et al. (2008) demonstrated that florfenicol tissue drug concentrations of seawater tilapia were lower than that in freshwater tilapia; and the elimination of florfenicol in seawater tilapia was more rapid than that in ...

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  • Pharmacokinetics of florfenicol in serum and synovial ...

    2019-10-24 · Objective—To define the pharmacokinetics of florfenicol in synovial fluid (SYNF) and serum from central venous (CV) and digital venous (DV) blood samples following regional IV perfusion (RIVP) of the distal portion of the hind limb in cows.. Animals—6 healthy adult cows.. Procedures—In each cow, IV catheters were placed in the dorsal common digital vein (DCDV) …

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  • Florfenicol - pharmacodynamic, pharmacokinetics and ...

    Pharmacodynamic, pharmacokinetics and clinical efficacy of florfenicol oral formulations in domestic animals were evaluated. For this purpose the systematic review and meta-analysis were done. In vitro efficacy of florfenicol showed that this drug is highly effective against most important respiratory pathogens.

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  • A Comparative Study of the Pharmacokinetics of ...

    A Comparative Study of the Pharmacokinetics of Conventional and Sustained-release Tablet Formulations of Aceclofenac in Healthy Male Subjects Santanu Ghosh* and BB Barik University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa.-751004, India. .

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  • Frontiers | Multi-Component Comparative Pharmacokinetics

    2020-6-19 · Citrus × aurantium L., Chinese name: Fructus Aurantii (FA) has been largely used as Qi-invigorating herb in China for centuries. The main components (meranzin hydrate, naringin, neohesperidin, meranzin, nobiletin) have good physiological activity with relatively high abundance in FA. Few multi-component comparative pharmacokinetics are simultaneously accessible for the …

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  • [PDF] Comparative Pharmacokinetics of Oral Ceftibuten ...

    DOI: 10.1002/j.1875-9114.1997.tb03684.x Corpus ID: 9537918. Comparative Pharmacokinetics of Oral Ceftibuten, Cefixime, Cefaclor, and Cefuroxime Axetil in Healthy Volunteers @article{Nix1997ComparativePO, title={Comparative Pharmacokinetics of Oral Ceftibuten, Cefixime, Cefaclor, and Cefuroxime Axetil in Healthy Volunteers}, author={D. Nix and W. Symonds and J. …

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  • Comparative Pulmonary Function and Pharmacokinetics of ...

    2011-9-30 · DPI-C uses reverse flow cyclone technology to retain larger particles in the device and to increase efficiency of respirable drug release. The study was conducted to determine comparative pharmacokinetics (not bioequivalence) of DPI-C and DPI-A (Advair Diskus®, GlaxoSmithKline) and to establish preliminary efficacy and safety of DPI-C.

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  • NCATS Inxight: Drugs — FLORFENICOL

    Comparative plasma pharmacokinetics and tolerance of florfenicol following intramuscular and intravenous administration to camels, sheep and goats. 2003 Sep 14582746

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  • Tissue pharmacokinetics of florfenicol in pigs ...

    The aim of this study has been to determine the tissue pharmacokinetic parameters of florfenicol in the pigs experimentally infected with Actinobacillus pleuropneumoniae. 21 crossed-bred (Duroc × Landrace × Yorkshire) local species of pigs were infected experimentally with Actinobacillus pleuropneumoniae serotype 1 and confirmed as typical sub-acute pleuropneumonia. A single …

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  • PHARMACOKINETICS OF FLORFENICOL IN LOGGERHEAD

    2003-3-1 · The pharmocodynamics of single injections of florfenicol in yearling loggerhead sea turtles (Caretta caretta) were determined. Eight juvenile loggerhead sea turtles weighing 1.25 (±0.18) kg were divided into two groups. Four animals received 30 mg/kg of florfenicol i.v., and four received the same dose i.m. Plasma florfenicol concentrations were analyzed by reverse-phase …

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  • Florfenicol for Chickens and Ducks - PoultryDVM

    Wang, Xiao, et al. Florfenicol causes excessive lipid peroxidation and apoptosis induced renal injury in broilers Ecotoxicology and Environmental Safety 207 (2021) Ismail, M., and Y. A. El-Kattan. Comparative pharmacokinetics of florfenicol in the chicken, pigeon and quail. British poultry science 50.1 (2009); hen, J., et al. Bioavailability and pharmacokinetics of florfenicol in broiler ...

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  • Comparative bioavailability between two routes of ...

    2011-7-29 · Florfenicol is a broad-spectrum time-dependent antimicrobial agent. Florfenicol is indicated in the treatment of bacterial pneumonia and associated respiratory infections in cattle and swine [1, 2]. The recommended dosage regimen for bovine is either a single dose of 40 mg/kg BW by SC route or two doses of 20 mg/kg BW by IM route with an ...

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  • A comparative study of the minimum inhibitory and mutant ...

    A comparative reference range was not available as enrofloxacin is not registered in South Africa for use in horses, and is used extra-labelly. The results for florfenicol against P. multocida yielded an MIC50 value of 0.5 µg/ml and an MPC50 value of <2 µg/ml. The …

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  • Comparative bioavailability of orally and vaginally ...

    2016-6-2 · Objective: To study the pharmacokinetics of progesterone (P) in healthy premenopausal female volunteers to compare the bioavailability of orally or vaginally administered hormone. Design: Subjects were randomly allocated to receive either oral P or a vaginal pessary then crossed over to the alternate preparation 1 month later.

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  • Frontiers | Comparative Study on Pharmacokinetics of Four ...

    2021-1-26 · A comparative study on pharmacokinetics of four long-acting enrofloxacin injectable formulations was investigated in 36 healthy pigs after intramuscular injection according to the recommended single dose @ 2.5 mg/kg body weight. The drug concentrations in the plasma were computed using high-performance liquid chromatography (HPLC) with fluorescence detection.

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  • A Systematic Review on Traditional Uses, Sources ...

    2020-3-25 · Comparative pharmacokinetics and preliminary pharmacodynamics evaluation of piscidin 1 against prv and pedv in rats. Frontiers in Chemistry, 6, 244-. 40. Lei Z, Liu Q, Qi Y, Yang B, Khaliq H, Xiong J, Moku GK, Ahmed S, Li K, Zhang H, Zhang W, Cao J, He Q.

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  • Pharmacokinetics of Florfenicol in the Red Pacu (Colossoma ...

    In rainbow trout (Oncorhynchus mykiss) kept at 10°C, an oral dose of 10 mg/kg had a mean residence time of 21 hours and a C MAX of 3.23 mcg/ml. 10 Pharmacokinetics have also been described for Atlantic salmon, Salmo salar. 11 Because chloramphenicol pharmacokinetics vary among animal species, a similar pattern was expected for florfenicol. 12 ...

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  • Pharmacokinetics of florfenicol in serum and synovial ...

    2019-10-24 · Objective—To define the pharmacokinetics of florfenicol in synovial fluid (SYNF) and serum from central venous (CV) and digital venous (DV) blood samples following regional IV perfusion (RIVP) of the distal portion of the hind limb in cows.. Animals—6 healthy adult cows.. Procedures—In each cow, IV catheters were placed in the dorsal common digital vein (DCDV) …

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  • DOISerbia - Florfenicol - pharmacodynamic ...

    Florfenicol - pharmacodynamic, pharmacokinetics and clinical efficacy of oral formulations in domestic animals: A systematic review Ščuka Leon (Krka d.d., Novo mesto, Ljubljana, Slovenija) Porcine respiratory disease complex (PRDC) is a major …

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  • Comparative Pharmacokinetics of d-Tubocurarine and ...

    Practice Guidelines for Moderate Procedural Sedation and Analgesia 2018: A Report by the American Society of Anesthesiologists Task Force on Moderate Procedural Sedation and Analgesia, the American Association of Oral and Maxillofacial Surgeons, American College of Radiology, American Dental Association, American Society of Dentist Anesthesiologists, and Society of …

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  • Article | Veterinární medicína

    Ali BH, Al-Qarawi AA, Hashaad M (2003): Comparative plasma pharmacokinetics and tolerance of florfenicol following intramuscular and intravenous administration to camels, sheep and goats. Veterinary Research Communications 27, 475–483.

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  • Frontiers | Comparative Study on Pharmacokinetics of Four ...

    2021-1-26 · A comparative study on pharmacokinetics of four long-acting enrofloxacin injectable formulations was investigated in 36 healthy pigs after intramuscular injection according to the recommended single dose @ 2.5 mg/kg body weight. The drug concentrations in the plasma were computed using high-performance liquid chromatography (HPLC) with fluorescence detection.

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  • Tylosin exposure reduces the susceptibility of Salmonella ...

    2020-1-28 · Kim MH, Gebru E, Chang ZQ, Choi JY, Hwang MH, Kang EH, et al. Comparative pharmacokinetics of tylosin or florfenicol after a single intramuscular administration at two different doses of tylosin-florfenicol combination in pigs. J Vet Med Sci. 2008;70:99–102. CAS PubMed Article Google Scholar 38.

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  • In Vitro and In Vivo Efficacy of Florfenicol for Treatment ...

    2020-12-17 · Francisella asiatica is a recently described, Gram-negative, facultative intracellular fish pathogen, known to be the causative agent of francisellosis in warm-water fish. Francisellosis outbreaks have increased in frequency among commercial aquaculture operations and have caused severe economic losses in every case reported. The lack of effective treatments for piscine …

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  • Phytochemistry, Traditional Uses and Pharmacological ...

    2021-7-12 · Title:Phytochemistry, Traditional Uses and Pharmacological Profile of Rose Hip: A Review VOLUME: 24 ISSUE: 35 Author(s):Zahra Ayati, Mohammad S. Amiri, Mahin Ramezani, Elahe Delshad, Amirhossein Sahebkar and Seyed A. Emami* Affiliation:Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Department …

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  • Comparative pharmacokinetics of florfenicol in the chicken ...

    2009-2-19 · 1. The pharmacokinetics of florfenicol were investigated in chickens (n = 20), pigeons (n = 30) and quails (n = 60) following intravenous (i.v.) and intramuscular (i.m.) administration of 30 mg/kg body weight.The concentration of florfenicol was measured using high performance liquid chromatography with ultraviolet detection.

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  • Phenicols - Pharmacology - Merck Veterinary Manual

    Florfenicol is available as an injectable solution intended for IM use. Distribution: Approximately 40%–60% of chloramphenicol in plasma is reversibly bound to albumin, and the free fraction readily diffuses into almost all tissues (including the brain); highest concentrations are reached in the kidneys, liver, and bile. Substantial ...

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  • HIPRA | Syringeability and viscosity comparative study

    Summary. All together, these findings indicate that the syringeabililty of the formulation is inversely proportional to its viscosity. The difference in performance between the products can be explained by different excipients in their formula. The contents of this page are country specific and aimed specifically at prescribing veterinarians.

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  • Comparative Study of Ocular Pharmacokinetics of ...

    2019-5-20 · solution was instilled by continuous lavage using the Morgan lens onto the left eyes at 15 mL/h (or 50 μL of the same solution repeatedly administered topically every hour). The animals were killed at 2, 4, 8, and 12 hours in the Morgan lens group or at 12 and 24 hours in the topical instillation group. Aqueous humor specimens were collected from the anterior chamber first, and …

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  • Pharmacokinetics and Bioequivalence Evaluation of Two ...

    In the fasted trial, the comparison of primary PK parameters between the test and reference products for the bioequivalence evaluation showed that the GMR (90% CI) values for C max, AUC 0–t, and AUC 0–∞ were 103.12% (96.88% to 109.76%), 102.24% (96.42% to 108.42%), and 102.16% (96.22% to 108.48%), respectively. All of the calculated 90% CIs were within the pre-defined …

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  • Singulair (Montelukast Sodium)

    2009-8-28 · The comparative pharmacokinetics of montelukast when administered as two 5-mg chewable tablets versus one 10-mg film-coated tablet have not been evaluated. Distribution . Montelukast is more than 99% bound to plasma proteins. The steady state volume of distribution of montelukast averages 8 to 11 liters.

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  • Ronald Baynes - NC State Veterinary Medicine

    2008-9-15 · Additional clinical uses of meropenem have regulatory approval in countries other than the United States, and clinical trials of meropenem for the treatment of a variety of conditions are ongoing. The optimization of meropenem dosing regimens also is discussed. Pharmacokinetic Properties of Meropenem Penetration

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  • Pharmacokinetic and Pharmacodynamic Properties of ...

    2009-9-25 · Comparative pharmacokinetics of MOX and IVM after oral administration to horses were also performed . Horses were treated orally with a gel formulation at the label dose of 0.4 mg of MOX per kg of body weight. Blood was collected over time and plasma assayed by high performance liquid chromatography with fluorescence detection.

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  • Moxidectin: a review of chemistry, pharmacokinetics and ...

    2021-7-17 · Abhisheak Sharma is a Research Assistant Professor at the Department of Pharmaceutics, University of Florida, Gainesville. He received his B. Pharm. from the Mohan Lal Sukhadia University, Udaipur, Indian in 2006 and became a registered pharmacist in India. He received his M. Pharm. in pharmaceutical chemistry from U. P. Technical University, Lucknow, …

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  • HIPRA | Syringeability and viscosity comparative study

    Summary. All together, these findings indicate that the syringeabililty of the formulation is inversely proportional to its viscosity. The difference in performance between the products can be explained by different excipients in their formula. The contents of this page are country specific and aimed specifically at prescribing veterinarians.

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  • Comparative Study of Ocular Pharmacokinetics of ...

    2019-5-20 · solution was instilled by continuous lavage using the Morgan lens onto the left eyes at 15 mL/h (or 50 μL of the same solution repeatedly administered topically every hour). The animals were killed at 2, 4, 8, and 12 hours in the Morgan lens group or at 12 and 24 hours in the topical instillation group. Aqueous humor specimens were collected from the anterior chamber first, and …

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  • Comparative metabolism as a key driver of wildlife species ...

    2014-11-19 · Comparative metabolism as a key driver of wildlife species sensitivity to human and veterinary pharmaceuticals. ... The human–fish plasma model provides a useful approach to understanding the pharmacokinetics of APIs (e.g. diclofenac, ibuprofen and propranolol) in freshwater fish, where gill and liver metabolism of APIs have been shown to be ...

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  • Pharmacokinetics and Toxicities of Oral Docetaxel ...

    Figure 1 Included patients.. Note: The number N represents the number of patients. Abbreviations: IV, intravenous; PK, pharmacokinetics. Notes: Patients included in the analysis. Study 1 = clinical Phase 1 study with once-weekly once-daily treatment with oral docetaxel (drinking solution, capsules (ModraDoc001, ModraDoc003, ModraDoc004) and tablets (ModraDoc006) co …

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  • Comparative absorption, distribution, and excretion of ...

    2013-3-26 · The in vivo kinetics of nanoparticles is an essential to understand the hazard of nanoparticles. Here, the absorption, distribution, and excretion patterns of titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles following oral administration were evaluated. Nanoparticles were orally administered to rats for 13 weeks (7 days/week).

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  • A Review of the Pharmacokinetics of Levothyroxine for the ...

    2020-1-10 · Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease associated with more than 2468 human infections and over 851 deaths in 27 countries ...

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  • Pharmacokinetics and Metabolism of Delamanid, a Novel

    2019-4-30 · Cyathulae Radix (CR), also known as “Chuanniux” is a well-known traditional Chinese herbal medicine that has been used in China for thousands of years. The present work reviewed advances in traditional uses, origin, chemical constituents, pharmacology, pharmacokinetics, and toxicity studies of CR. This work aims to provide more up-to-date references for modern study …

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  • Comparative therapeutic efficacy of remdesivir and ...

    Such application would provide a major step toward assuring a safe food supply under a wide variety of dose and off-label clinical uses. Population pharmacokinetics is an ideal method for generating data in support of the implementation of flexible labelling policies and extralabel drug use recently approved under AMDUCA (Animal Medicinal Drug ...

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  • (PDF) Pharmacokinetics of florfenicol in cod Gadus morhua ...

    Pharmacokinetics of florfenicol in cod Gadus morhua and in vitro antibacterial activity against Vibrio anguillarum. Ole Samuelsen. ø. Bergh. Ole Samuelsen. ø. Bergh. Related Papers. Efficacy of orally administered flumequine in the treatment of vibriosis caused by Listonella anguillarum in Atlantic cod Gadus morhua.

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  • Pharmacokinetics of Clindamycin in Loggerhead Sea Turtles ...

    2011-12-1 · Comparative in vitro activities of XRP 2868, pristinamycin, quinupristin-dalfopristin, vancomycin, daptomycin, linezolid, clarithromycin, telithromycin, clindamycin, and ampicillin against anaerobic Gram-positive species, Actinomycetes, and Lactobacilli ... Pharmacokinetics of florfenicol in loggerhead sea turtles (Caretta caretta) after single ...

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  • Aquaflor (Florfenicol) 50% Type A Medicated Article for ...

    florfenicol has a melting point of 153.5 - 154.5”C. Florfenicol is a nonvolatile solid and has a UV maximum at 224 nm. In view of these physico-chemical characteristics, and those listed for the metabolites in Table 1, it is unlikely that florfenicol, or its metabolites, will pose potential risks to …

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  • Journal of the Preventive Veterinary Medicine

    Prieb S, Schwarz S. In vitro activities of florfenicol against bovine and porcine respiratory tract pathogens. Antimicrob Agents Chemother. 2003, 47(8):2703-2705. 21.Shen J, Hu D, Wu X, Coats JR. Bioavailability and pharmacokinetics of florfenicol in broiler 22.

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  • Synovial fluid pharmacokinetics of tulathromycin ...

    2015-2-7 · Deep digital septic conditions represent some of the most refractory causes of severe lameness in cattle. The objective of this study was to determine the distribution of tulathromycin, gamithromycin and florfenicol into the synovial fluid of the metatarsophalangeal (MTP) joint of cattle after single subcutaneous administration of drug to evaluate the potential usefulness of these …

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  • In Vitro and In Vivo Efficacy of Florfenicol for Treatment ...

    2020-12-17 · Francisella asiatica is a recently described, Gram-negative, facultative intracellular fish pathogen, known to be the causative agent of francisellosis in warm-water fish. Francisellosis outbreaks have increased in frequency among commercial aquaculture operations and have caused severe economic losses in every case reported. The lack of effective treatments for piscine …

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  • Comparative absorption, distribution, and excretion of ...

    2013-3-26 · The in vivo kinetics of nanoparticles is an essential to understand the hazard of nanoparticles. Here, the absorption, distribution, and excretion patterns of titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles following oral administration were evaluated. Nanoparticles were orally administered to rats for 13 weeks (7 days/week).

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  • Moxidectin: a review of chemistry, pharmacokinetics and ...

    2009-9-25 · Comparative pharmacokinetics of MOX and IVM after oral administration to horses were also performed . Horses were treated orally with a gel formulation at the label dose of 0.4 mg of MOX per kg of body weight. Blood was collected over time and plasma assayed by high performance liquid chromatography with fluorescence detection.

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  • A Comparative Study of a Preservative-Free Latanoprost ...

    2019-9-9 · Purpose: Benzalkonium chloride (BAK), a common preservative in eye drops, can induce ocular surface toxicity that may decrease glaucoma therapy compliance. The ocular hypotensive effect, pharmacokinetic (PK) profiles, and local tolerance of a preservative-free latanoprost 0.005% cationic emulsion (Catioprost ®), and a BAK-preserved latanoprost 0.005% solution (Xalatan ®), …

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  • A Review of the Pharmacokinetics and Pharmacodynamics

    2021-3-18 · Because the pharmacokinetics of remifentanil are linear and close to a one-compartment model, its whole blood concentration can be estimated as 20–30 times the infusion rate after it has been maintained for 10 min, e.g., an infusion of 0.25 μg · kg −1 · min −1 is approximately equal to 7.5 ng/mL.

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  • Plasma concentrations resulting from florfenicol ...

    Consequently, plasma concentrations of florfenicol in this study indicate an apparent decrease in bioavailability as compared with studies of pharmacokinetics detailed by Liu et al. (2003). This may be explained by a smaller dose delivered to pigs, derived from the reduced water intake observed in this study plus the nonquantified water spillage.

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  • Impact of therapeutic and high doses of florfenicol on ...

    2017-3-21 · Aim: The aim of this study was to evaluate the impact of therapeutic and high doses of florfenicol on kidney and liver functional indicators in goat species. Materials and Methods: Six mature, healthy goats (combine breed and sex) with average weight 25 kg were selected for this study. The therapeutic (20 mg/kg b.w.) and high doses (40 and 60 mg) of florfenicol were …

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  • Lisa Tell | School of Veterinary Medicine

    2019-12-2 · Comparative pharmacokinetics of two florfenicol formulations following intramuscular and subcutaneous administration to sheep. 2018 Yamasaki YK, Graves EE, Houston RS, OConnor BM, Kysar PE, Straub MH, Foley JE, Tell LA

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  • Journal of Veterinary Pharmacology and Therapeutics ...

    Comparative pharmacokinetics of enrofloxacin in healthy and Aeromonas hydrophila-infected crucian carp (Carassius auratus gibelio) ... Diffusion-limited PBPK model for predicting pulmonary pharmacokinetics of florfenicol in pig: M. Mohammadsadegh · M. Mohammadsadegh Pharmacokinetics of grapiprant, a selective EP4 prostaglandin PGE2 receptor ...

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  • Pharmacokinetic and pharmacodynamic integration for ...

    2020-10-15 · Wilson WD, Mihalyi JE (1998) Comparative pharmacokinetics of ceftiofur in neonatal foals and adult horses. In: Neonatal Septicemia Workshop II. Davis, p 1. 40. ElSayed M, ElKomy A, Elbarawy A, Ibrahim D (2015) Pharmacokinetics and tissue residues of ceftiofur in normal and Escherichia coli infected chickens. J Physiol Pharmacol Adv 5:574.

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  • Assessment of Comparative Immunogenicity in Biosimilar ...

    Abstract Number: 605. Assessment of Comparative Immunogenicity in Biosimilar Development: Immunogenicity and Pharmacokinetics Following a Single Dose of M923, a Proposed Biosimilar for Reference Adalimumab (HUMIRA®), Compared with US- and EU-Sourced Reference Adalimumab in Healthy Subjects

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  • Ronald Baynes - NC State Veterinary Medicine

    RESUMO. Determinou-se a concentração eficaz de oxitetraciclina (OTC) e florfenicol (FFC) no tratamento de Aeromonas hydrophila em pacu (Piaractus. mesopotamicus).Os pacus foram submetidos à captura duas vezes ao dia por quatro dias e em seguida foram infectados com A. hydrophila (2,4x10 7 bactéria mL-1).Os tratamentos utilizados foram: controle sem infecção …

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