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comparative pharmacokinetics of florfenicol using method

  • Comparative pharmacokinetics of florfenicol in

    Pasteurella multocida is the causative agent of fowl cholera, and florfenicol (FF) has potent antibacterial activity against P. multocida and is widely used in the poultry industry. In this study, we established a P. multocida infection model in ducks and studied the pharmacokinetics of FF in serum …

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  • Comparative muscle irritation and pharmacokinetics

    Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs. Florfenicol (FF) is a novel animal-specific amidohydrin broad-spectrum antibiotic.

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  • Comparative plasma pharmacokinetics and tolerance

    Florfenicol, a monofluorinated analogue of thiamphenicol, has a broad antibacterial spectrum. The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats. The concentration of florfenicol in plasma was determined ...

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  • Comparative pharmacokinetics of florfenicol in the

    1. The pharmacokinetics of florfenicol were investigated in chickens (n = 20), pigeons (n = 30) and quails (n = 60) following intravenous (i.v.) and intramuscular (i.m.) administration of 30 mg/kg body weight. The concentration of florfenicol was measured using high performance liquid chromatography …

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  • Comparative pharmacokinetics of florfenicol in

    2019-3-25 · Pasteurella multocida is the causative agent of fowl cholera, and florfenicol (FF ) has potent antibacterial activity against P. multocida and is widely used in the poultry industry. In this study, we established a P. multocida infection model in ducks and studied the pharmacokinetics of FF in serum and lung tissues after oral administration of 30 mg/kg bodyweight.

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  • Comparative pharmacokinetics of florfenicol in the

    2009-1-1 · 1. The pharmacokinetics of florfenicol were investigated in chickens (n = 20), pigeons (n = 30) and quails (n = 60) following intravenous (i.v.) and intramuscular (i.m.) administration of 30 mg/kg body weight. The concentration of florfenicol was measured using high performance liquid chromatography with ultraviolet detection. 2.

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  • COMPARATIVE ALLOMETRIC ANALYSIS OF

    2006-7-5 · Comparative allometric analysis of pharmacokinetics of florfenicol and tiamphenicol 116 BJVM, 9, No 2 (Jianzhong et al., 2003). Florfenicol ex-hibits a broad antibacterial spectrum and a strong antibacterial activity, similar to those of chloramphenicol. At …

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  • Comparative muscle irritation and pharmacokinetics

    2019-11-13 · Florfenicol (FF) is a novel animal-specific amidohydrin broad-spectrum antibiotic. However, its aqueous solubility is extremely poor, far below the effective dose required for veterinary clinic.

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  • Comparative Plasma Pharmacokinetics and Tolerance

    Florfenicol, a monofluorinated analogue of thiamphenicol, has a broad antibacterial spectrum. The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats.

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  • Comparative single-dose pharmacokinetics of orally ...

    This study evaluates changes in the pharmacokinetic behavior of a single oral dose of florfenicol in rainbow trouts experimentally infected with Lactococcus garvieae or Streptococcus iniae. One hundred and fifty fish were randomly divided into three equal groups: 1-healthy fish, 2-fish inoculated with S. iniae (2.87 × 107 CFU/ml, i.p.), and 3-fish inoculated with L. garvieae (6.8 × 105 CFU/ml, i.p.).

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  • Comparative pharmacokinetics of florfenicol in

    2019-3-25 · Pasteurella multocida is the causative agent of fowl cholera, and florfenicol (FF ) has potent antibacterial activity against P. multocida and is widely used in the poultry industry. In this study, we established a P. multocida infection model in ducks and studied the pharmacokinetics of FF in serum and lung tissues after oral administration of 30 mg/kg bodyweight.

    Get Price
  • Comparative pharmacokinetics of florfenicol in the

    2009-1-1 · 1. The pharmacokinetics of florfenicol were investigated in chickens (n = 20), pigeons (n = 30) and quails (n = 60) following intravenous (i.v.) and intramuscular (i.m.) administration of 30 mg/kg body weight. The concentration of florfenicol was measured using high performance liquid chromatography with ultraviolet detection. 2.

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  • Comparative single‐dose pharmacokinetics of orally ...

    2018-11-25 · Florfenicol was administered to all groups at 15 mg/kg by oral gavage. Blood sampling was performed at 0, 2, 3, 6, 8, 12, 24, 48, 72, and 120 hr after drug administration to each group, and plasma concentration of florfenicol was assayed by HPLC method.

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  • Comparative Plasma Pharmacokinetics and Tolerance

    Florfenicol, a monofluorinated analogue of thiamphenicol, has a broad antibacterial spectrum. The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats. The concentration of florfenicol in plasma was determined using a microbiological assay.

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  • [PDF] Pharmacokinetics of Florfenicol in Healthy Pigs

    ABSTRACT A comparative in vivo pharmacokinetic study of florfenicol was conducted in 18 crossbred pigs infected with Actinobacillus pleuropneumoniae following intravenous (i.v.), intramuscular (i.m.), or oral (p.o.) administration of a single dose of 20 mg/kg. The disease model was confirmed by clinical signs, X rays, pathohistologic examinations, and organism isolation.

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  • FLORFENICOL PHARMACODYNAMIC,

    2006-6-16 · in comparative control groups in all observed parameters: clinical signs, lung lesions and reisolation of Actinobacillus pleuropneumo-niae (P<0.001). A second meta-analysis with 7 studies showed that the usage of florfenicol reduces mortality in pig herds with PRDC (P<0.05). Other field trials in pigs using florfenicol oral forms where re-viewed.

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  • Temperature-dependent pharmacokinetics of

    2017-4-21 · The florfenicol concentration in plasma samples was analyzed using a high performance liquid chromatography (HPLC) method, with UV detector at 223 nm. The mobile phase (acetonitrile:water v/v 26/74) was delivered at a constant flow rate of 1mL·min -1 .

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  • Bioavailability and pharmacokinetics of florfenicol in ...

    2019-3-30 · Comparative pharmacokinetics of florfenicol in Japanese eels at different temperature Anim. Husb. Feed Sci. , 7 ( 2015 ) , pp. 126 - 130 View Record in Scopus Google Scholar

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  • Frontiers | Comparative Pharmacokinetics of

    2004-6-9 · Florfenicol concentrations in serum were determined by a validated high‐performance liquid chromatography method with UV detection at a wavelength of 223 nm in which serum samples were spiked with chloramphenicol as internal standard.

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  • Comparative muscle irritation and pharmacokinetics

    Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs. Florfenicol (FF) is a novel animal-specific amidohydrin broad-spectrum antibiotic.

    Get Price
  • Comparative plasma pharmacokinetics and tolerance

    Florfenicol, a monofluorinated analogue of thiamphenicol, has a broad antibacterial spectrum. The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats. The concentration of florfenicol in plasma was determined ...

    Get Price
  • Comparative pharmacokinetics of florfenicol in the

    2009-1-1 · 1. The pharmacokinetics of florfenicol were investigated in chickens (n = 20), pigeons (n = 30) and quails (n = 60) following intravenous (i.v.) and intramuscular (i.m.) administration of 30 mg/kg body weight. The concentration of florfenicol was measured using high performance liquid chromatography with ultraviolet detection. 2.

    Get Price
  • COMPARATIVE ALLOMETRIC ANALYSIS OF

    2006-7-5 · Comparative allometric analysis of pharmacokinetics of florfenicol and tiamphenicol 116 BJVM, 9, No 2 (Jianzhong et al., 2003). Florfenicol ex-hibits a broad antibacterial spectrum and a strong antibacterial activity, similar to those of chloramphenicol. At …

    Get Price
  • Comparative muscle irritation and pharmacokinetics

    2019-11-13 · Florfenicol (FF) is a novel animal-specific amidohydrin broad-spectrum antibiotic. However, its aqueous solubility is extremely poor, far below the effective dose required for veterinary clinic.

    Get Price
  • Comparative single-dose pharmacokinetics of orally ...

    This study evaluates changes in the pharmacokinetic behavior of a single oral dose of florfenicol in rainbow trouts experimentally infected with Lactococcus garvieae or Streptococcus iniae. One hundred and fifty fish were randomly divided into three equal groups: 1-healthy fish, 2-fish inoculated with S. iniae (2.87 × 107 CFU/ml, i.p.), and 3-fish inoculated with L. garvieae (6.8 × 105 CFU/ml, i.p.).

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  • Comparative single‐dose pharmacokinetics of orally ...

    2018-11-25 · Florfenicol was administered to all groups at 15 mg/kg by oral gavage. Blood sampling was performed at 0, 2, 3, 6, 8, 12, 24, 48, 72, and 120 hr after drug administration to each group, and plasma concentration of florfenicol was assayed by HPLC method.

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  • Comparative single‐dose pharmacokinetics of orally ...

    2018-11-25 · Florfenicol was administered to all groups at 15 mg/kg by oral gavage. Blood sampling was performed at 0, 2, 3, 6, 8, 12, 24, 48, 72, and 120 hr after drug administration to each group, and plasma concentration of florfenicol was assayed by HPLC method. The MICs of florfenicol were 1.2 μg/ml and 5 μg/ml against L. garviae and S. iniae, respectively.

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  • Comparative muscle irritation and pharmacokinetics

    A comparison was conducted between FF and FF-HP-β-CD freeze-dried powder injection of their muscle irritation and the pharmacokinetics. The drug loading and saturated solubility of FF-HP-β-CD at 37 °C were 11.78% ± 0.04% and 78.93 ± 0.42 mg/mL, respectively (35.4-fold compared with FF).

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  • FLORFENICOL PHARMACODYNAMIC,

    2006-6-16 · By comparing the pharmacokinetic parameters from fasted and fedpigs after oral administration of florfenicol, it is suggested that both bioavailabili-ties were similar and the half-lives of elimination were rather long. The high Cmaxwas reached in 1 h and 2 h in fasted and fed pigs, respectively. The results showedthat feeding has little impact on absorbtion of florfenicol and …

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  • Comparative pharmacokinetics of two florfenicol ...

    2019-10-24 · OBJECTIVE To compare the pharmacokinetics of 2 commercial florfenicol formulations following IM and SC administration to sheep.. ANIMALS 16 healthy adult mixed-breed sheep.. PROCEDURES In a crossover study, sheep were randomly assigned to receive florfenicol formulation A or B at a single dose of 20 mg/kg, IM, or 40 mg/kg, SC. After a 2-week washout period, each sheep …

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  • Comparative plasma pharmacokinetics and tolerance

    The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats. The concentration of florfenicol in plasma was determined using a microbiological assay.

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  • Pharmacokinetics of florfenicol and its metabolite ...

    2008-2-1 · Florfenicol is not subject to the action of acetyltransferase, which is an enzyme used by bacteria to develop resistance to chloramphenicol and thiamphenicol (Cannon et al., 1990, Paape et al., 1990). Because of the emergence of resistant strains of micro-organisms, there may be great value in using florfenicol for therapeutic use in dogs.

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  • [PDF] Pharmacokinetics and Bioequivalence of

    A pharmacokinetic and bioequivalence evaluation of two florfenicol oral solutions was carried out in 28 healthy broiler chickens after oral administration of a single dose of 20 mg/kg bw, according to a randomized, parallel experimental design. The two formulations were: Flonicol® (Mobedco, Jordan) as a test product and Veterin®10% (Centrovet, Chile) as a reference product.

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  • Pharmacokinetics of florfenicol after intravenous and ...

    2013-10-1 · Florfenicol, is a broad spectrum antimicrobial agent with wide tissue distribution commonly used to treat camelids. To address the lack of drug disposition data for florfenicol in llamas, we evaluated the pharmacokinetics after 20 mg/kg intravenous (i.v.) and intramuscular (i.m.) dosing.Serum concentrations were determined using a HPLC-UV assay and pharmacokinetic analysis was conducted using ...

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  • Comparative pharmacokinetics of oxytetracycline in

    2018-10-1 · Comparative pharmacokinetics of oxytetracycline in tilapia ... with uniform weighting using sparse data option available in the software. In this method, mean OTC concentration curve of the data was generated by taking the mean concentration value of the plasma data (n = 6) for each time point. ... demonstrated that florfenicol tissue drug ...

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  • Florfenicol | C12H14Cl2FNO4S - PubChem

    Quinolones are currently the most commonly used group of antimicrobial agents in Norwegian aquaculture. The aims of this study were to examine and compare the pharmacokinetic properties of the quinolones oxolinic acid, flumequine, sarafloxacin, and enrofloxacin after intravascular and oral administration to Atlantic salmon (Salmo salar) by using identical experimental designs.

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  • Comparative single-dose pharmacokinetics of four ...

    The method of McKellar et al. (1999) was used for analysis of ENR levels in plasma. HPLC separation was carried out by using a mobile phase containing 14% acetonitrile, 85% water, 0.4% triethylamine, and 0.6% phosphoric acid. The mobile phase was filtered by using a 0.45 μm membrane filter.

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  • Comparative pharmacokinetics of two florfenicol ...

    2019-10-24 · OBJECTIVE To compare the pharmacokinetics of 2 commercial florfenicol formulations following IM and SC administration to sheep.. ANIMALS 16 healthy adult mixed-breed sheep.. PROCEDURES In a crossover study, sheep were randomly assigned to receive florfenicol formulation A or B at a single dose of 20 mg/kg, IM, or 40 mg/kg, SC. After a 2-week washout period, each sheep …

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  • [PDF] Pharmacokinetics and Bioequivalence of

    A pharmacokinetic and bioequivalence evaluation of two florfenicol oral solutions was carried out in 28 healthy broiler chickens after oral administration of a single dose of 20 mg/kg bw, according to a randomized, parallel experimental design. The two formulations were: Flonicol® (Mobedco, Jordan) as a test product and Veterin®10% (Centrovet, Chile) as a reference product.

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  • [PDF] PHARMACOKINETICS OF FLORFENICOL VIA

    The purpose of this study was to evaluate the pharmacokinetic behavior of florfenicol spray-dried nanosuspersion after oral administration to rabbits and to compare its oral bioavailability characteristics to that of a known soluble powder. Florfenicol spray-dried nanosuspersion was produced by high pressure homogenization followed by spray drying. Plasma concentrations were determined by HPLC ...

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  • Pharmacokinetics of florfenicol following intravenous

    1994-8-1 · The disposition of florfenicol after single intravenous and intramuscular doses of 20 mg of florfenicol/kg of body weight (b.w.) to feeder calves was investigated. Serum florfenicol concentrations were determined by a sensitive high performance liquid chromatographic method with a limit of quantitation of 0.025 μg/ml. The extent of serum protein binding of florfenicol was only 13.2% at a ...

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  • [PDF] Pharmacokinetics of florfenicol in cod Gadus

    The pharmacokinetic profile of the antibacterial agent florfenicol was studied in plasma after intravenous (i.v.) injection and in plasma, muscle and liver following oral (p.o.) administration to cod Gadus morhua, held in seawater at 8 degrees C and weighing 100 to 200 g. Following i.v. injection, the plasma drug concentration-time profile showed 2 distinct phases.

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  • Pharmacokinetics of Florfenicol in the Red Pacu

    2020-8-14 · In rainbow trout (Oncorhynchus mykiss) kept at 10°C, an oral dose of 10 mg/kg had a mean residence time of 21 hours and a C MAX of 3.23 mcg/ml. 10 Pharmacokinetics have also been described for Atlantic salmon, Salmo salar. 11 Because chloramphenicol pharmacokinetics vary among animal species, a similar pattern was expected for florfenicol. 12 ...

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  • Pharmacokinetic parameters and optimal dosage of a ...

    The aims of this study were to evaluate the in vitro antibacterial activity of a florfenicol and tylosin mixture and to determine the pharmacokinetic parameters of each drug following administration of the 2 : 1 florfenicol and tylosin mixture in beagle dogs. The antibacterial activity of the two antibiotics, both singly and as a mixture, was investigated in bacteria isolated from 119 beagle dogs.

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  • A comparative study of the minimum inhibitory and

    method used was the standardized microdilution method performed in microtitre plates. The MPC method used was according to the method described by Blondeau. This method was modified, to make use of smaller plates and lower volumes of antimicrobials, but retaining a final bacterial concentration of 109 colony-forming units per ml.

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  • Frontiers | Multi-Component Comparative

    2020-6-19 · Citrus × aurantium L., Chinese name: Fructus Aurantii (FA) has been largely used as Qi-invigorating herb in China for centuries. The main components (meranzin hydrate, naringin, neohesperidin, meranzin, nobiletin) have good physiological activity with relatively high abundance in FA. Few multi-component comparative pharmacokinetics are simultaneously accessible for the flavone …

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  • Comparative pharmacokinetics of fluralaner in dogs

    2016-5-31 · Background Bravecto™ Chewable Tablets for Dogs, containing fluralaner as active ingredient, is an innovative treatment for flea and tick infestations that provides safe, rapid and long acting efficacy after a single oral administration in dogs. Topically applied fluralaner provides similar safe, rapid and long acting efficacy, both in dogs and in cats. The pharmacokinetic profile of ...

    Get Price
  • Comparative Plasma Pharmacokinetics and Tolerance

    2004-10-8 · Florfenicol, a monofluorinated analogue of thiamphenicol, has a broad antibacterial spectrum. The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats. The concentration of florfenicol in plasma was determined using a microbiological assay. …

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  • Comparative bioavailability between two routes of ...

    2011-7-29 · Comparative bioavailability between two routes of administration of florfenicol and ... PHARMACOKINETICS AND STATISTICAL ANALYSIS A non-compartmental analysis (NCA) of florfenicol and ... Results of the validation method for florfenicol and flunixin. Revue Méd. Vét., 2011, 162, 6, 321-324 XXXXX 323 Results and Discussion

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  • VetCAST Method for Determination of the

    2019-6-12 · Results of clinical trials for florfenicol were comprehensively analyzed using a mixed-treatment comparison meta-analysis, which combined evidence from published trials and published estimates of comparative efficacy for 12 AMDs registered for use in the USA (O'Connor et al., 2016). It was concluded that florfenicol was efficacious, ranking ...

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  • Pharmacokinetics of Florfenicol in Healthy Pigs and in ...

    examinations, and organism isolation. Florfenicol concentrations in plasma were determined by a validated high-performance liquid chromatography method with UV detection at a wavelength of 223 nm. Pharmacoki-netic parameters were calculated by using the MCPKP software (Research Institute of Traditional Chinese Veterinary Medicine, Lanzhou, China).

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  • [PDF] Pharmacokinetics of florfenicol following ...

    Florfenicol is a synthetic broad-spectrum antibiotic used to treat infectious diseases in veterinary medicine. Limited information is available on the pharmacokinetics and bioavailability of florfenicol in dogs. This study was conducted in six healthy dogs to determine the bioavailability and pharmacokinetics of florfenicol following a single intravenous ( i.v.) and intramuscular ( i.m.) dose ...

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  • Pharmacokinetics and tissue depletion of florfenicol in ...

    2010-10-1 · Florfenicol (Ff) is a synthetic antibiotic with a broad antibacterial spectrum and high therapeutic effectiveness that was specifically developed for veterinary use. In the present study, tissue residual levels and the pharmacokinetics of Ff after oral administration of 30 mg/kg to Leghorn and Taiwan Native chicken were studied.

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  • Plasma and Tissue Depletion of Florfenicol and

    2008-10-31 · Chickens were used to investigate plasma disposition of florfenicol after single intravenous (i.v.) and oral dose (20 mg kg−1 body weight) and to study residue depletion of florfenicol and its major metabolite florfenicol-amine after multiple oral doses (40 mg kg−1 body weight, daily for 3 days). Plasma and tissue samples were analyzed using a high-performance liquid chromatography (HPLC ...

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  • Development and validation of a method for

    2021-3-30 · Method validation. To quantify more accurately, the internal standard is used to correct the final results. Calibration curves for FF and FFA in the blank matrixes at concentrations of 1, 2, 5, 10, 25, 50, 100 and 200 ng/mL (mixed with 50 μg/kg internal standard) were constructed by drawing the relationship between the peak areas (y-axis) and concentration (x-axis).

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  • Compositions containing prodrugs of florfenicol and ...

    2007-10-10 · 1. 1-24. (canceled) 25. A method of treating a bacterial infection in a bovine comprising administering to the bovine a composition comprising a florfenicol ester and a pharmaceutically acceptable solvent wherein the florfenicol ester is selected from the group consisting of florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol heptanoate ...

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  • (PDF) Comparative Pharmacokinetics of Gentamicin in

    The elimination of gentamicin residues in eggs was reported by Filazi et al. 8 . When administered to laying hens via IM or SC routes, gentamicin was deposited in egg yolk and albumen, with residues persisting for longer periods in the yolk 8,9 .Although the aminoglycosides have been extensively reviewed, few studies on the pharmacokinetics of ...

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  • eCite - Pharmacokinetics of Florfenicol in Healthy Pigs ...

    A comparative in vivo pharmacokinetic study of florfenicol was conducted in 18 crossbred pigs infected with Actinobacillus pleuropneumoniae following intravenous (i.v.), intramuscular (i.m.), or oral (p.o.) administration of a single dose of 20 mg/kg. The disease model was confirmed by clinical signs, X rays, pathohistologic examinations, and organism isolation.

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  • Pharmacokinetics of florfenicol and its major

    2007-2-1 · The pharmacokinetics of florfenicol and its active metabolite florfenicol amine were investigated in rabbits after a single intravenous (i.v.) and oral (p.o.) administration of florfenicol at 20 mg/kg bodyweight. The plasma concentrations of florfenicol and florfenicol amine were determined simultaneously by an LC/MS method. After i.v. injection, the terminal half‐life (t1/2λz), steady ...

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  • Tissue pharmacokinetics of florfenicol in pigs ...

    The aim of this study has been to determine the tissue pharmacokinetic parameters of florfenicol in the pigs experimentally infected with Actinobacillus pleuropneumoniae. 21 crossed-bred (Duroc × Landrace × Yorkshire) local species of pigs were infected experimentally with Actinobacillus pleuropneumoniae serotype 1 and confirmed as typical sub-acute pleuropneumonia. A single dose of 20mg/kg ...

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  • Pharmacokinetics of Florfenicol in the Red Pacu

    2020-8-14 · In rainbow trout (Oncorhynchus mykiss) kept at 10°C, an oral dose of 10 mg/kg had a mean residence time of 21 hours and a C MAX of 3.23 mcg/ml. 10 Pharmacokinetics have also been described for Atlantic salmon, Salmo salar. 11 Because chloramphenicol pharmacokinetics vary among animal species, a similar pattern was expected for florfenicol. 12 ...

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  • Frontiers | Comparative Pharmacokinetics of

    2020-1-24 · Comparative Pharmacokinetics of Hydrophilic Components in Salvia miltiorrhiza Bge. and Carthamus tinctorius L. in Rats That Underwent Cerebral Ischemia Reperfusion Using an HPLC-DAD Method Xixi Zhao 1† , Li Yu 1† , Yulin Chen 1 , Yu Wang 1 , Haitong Wan 1* and Jiehong Yang 2*

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  • Clinical efficacy of florfenicol administered in the ...

    2019-4-15 · screening method for the evaluation of antimicrobial sensitivity. A study evaluated the efficacy of three antimicrobial drugs in an in vivo infection model against ORT in turkeys*that is, enrofloxacin (10 mg/kg), amoxicillin and florfenicol (FF) (both 20 mg/kg)*and enrofloxacin was found the most successful drug, followed by FF (Marien et al ...

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  • Comparative pharmacokinetics of Ding‐Zhi‐Xiao‐Wan ...

    2021-2-1 · The pharmacokinetics of cefoperazone, cefotaxime, and moxalactam were compared in a cross-over randomized study in 10 healthy volunteers. Each subject received 1.0 g of the three drugs by bolus intravenous injection over 3 min. Serum and urine concentrations were assayed by a microbiological method and in addition by high-pressure liquid chromatography (HPLC) for cefotaxime …

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  • Comparative pharmacokinetics of cefoperazone,

    2016-5-31 · Background Bravecto™ Chewable Tablets for Dogs, containing fluralaner as active ingredient, is an innovative treatment for flea and tick infestations that provides safe, rapid and long acting efficacy after a single oral administration in dogs. Topically applied fluralaner provides similar safe, rapid and long acting efficacy, both in dogs and in cats. The pharmacokinetic profile of ...

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  • Comparative pharmacokinetics of fluralaner in dogs

    platin. Using a conversion factor of 3 (5), the equivalents in mg/m2 are calculated, as mentioned in Table 1. Pharmacokinetics. For each of the analogues semilogarithmic plots of total platinum, free platinum, and concentrations of free parent drug in plasma or plasma ultrafiltrate are shown in Fig. 1.

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  • Comparative Pharmacokinetics of Tylosin or

    Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs Mi-Hee KIM , Elias GEBRU , Zhi-Qiang CHANG , Jae-Young CHOI , Mi-Hyun HWANG , Eun-Hee KANG , …

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  • Pharmacokinetics of florfenicol in cod Gadus morhua

    2003-9-24 · The in vitro minimum inhibitory concentration (MIC) values of florfenicol against 3 Vibrio anguillarum strains isolated from diseased cod (A-21, HI-610, HI-618) were 0.5 microg ml(-1) for all 3 strains. PMID: 14598988 [Indexed for MEDLINE] Publication Types: Comparative Study; MeSH terms. Animals; Anti-Bacterial Agents/pharmacokinetics*

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  • Florfenicol pharmacokinetics in lactating cows after ...

    Pharmacokinetics of florfenicol 30% injectable solution was determined in lactating cows after intravenous, intramammary and intramuscular administration. Serum concentration-time data generated in the present study were analysed by non-compartmental methods based on statistical moment theory.

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  • Florfenicol - pharmacodynamic, pharmacokinetics and ...

    Pharmacodynamic, pharmacokinetics and clinical efficacy of florfenicol oral formulations in domestic animals were evaluated. For this purpose the systematic review and meta-analysis were done. In vitro efficacy of florfenicol showed that this drug is highly effective …

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  • Clinical efficacy of florfenicol administered in the ...

    2019-4-15 · screening method for the evaluation of antimicrobial sensitivity. A study evaluated the efficacy of three antimicrobial drugs in an in vivo infection model against ORT in turkeys*that is, enrofloxacin (10 mg/kg), amoxicillin and florfenicol (FF) (both 20 mg/kg)*and enrofloxacin was found the most successful drug, followed by FF (Marien et al ...

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  • Frontiers | Comparative Study on Pharmacokinetics of

    2021-1-26 · A comparative study on pharmacokinetics of four long-acting enrofloxacin injectable formulations was investigated in 36 healthy pigs after intramuscular injection according to the recommended single dose @ 2.5 mg/kg body weight. The drug concentrations in the plasma were computed using high-performance liquid chromatography (HPLC) with fluorescence detection.

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  • Comparative Pharmacokinetics of a Compounded 6 ...

    2011-3-29 · Comparative Pharmacokinetics of a Compounded 6-mercaptopurine Liquid Formulation Preparation and Tablets The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

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  • Comparative analysis of pharmacokinetics of

    2017-7-13 · (13) Xie L L, Wu Z X*, Chen X X*, Li Q, Yuan J, Liu H, Yang Y. Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in rice field eel (Monopterus albus) after a signle-dose intramuscular or oral administration.

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  • Research Paper Comparative In Vitro Properties and ...

    2020-10-23 · (2020). Comparative analysis of pharmacokinetics of vancomycin hydrochloride in rabbits after ocular, intragastric, and intravenous administration by LC …

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  • eCite - Pharmacokinetics of Florfenicol in Healthy Pigs ...

    A comparative in vivo pharmacokinetic study of florfenicol was conducted in 18 crossbred pigs infected with Actinobacillus pleuropneumoniae following intravenous (i.v.), intramuscular (i.m.), or oral (p.o.) administration of a single dose of 20 mg/kg. The disease model was confirmed by clinical signs, X rays, pathohistologic examinations, and organism isolation.

    Get Price
  • Florfenicol - pharmacodynamic, pharmacokinetics and ...

    Pharmacodynamic, pharmacokinetics and clinical efficacy of florfenicol oral formulations in domestic animals were evaluated. For this purpose the systematic review and meta-analysis were done. In vitro efficacy of florfenicol showed that this drug is highly effective …

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  • PHARMACOKINETICS OF FLORFENICOL IN

    2003-3-1 · The pharmocodynamics of single injections of florfenicol in yearling loggerhead sea turtles (Caretta caretta) were determined. Eight juvenile loggerhead sea turtles weighing 1.25 (±0.18) kg were divided into two groups. Four animals received 30 mg/kg of florfenicol i.v., and four received the same dose i.m. Plasma florfenicol concentrations were analyzed by reverse-phase high performance ...

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  • Florfenicol pharmacokinetics following intravenous

    Concentrations of florfenicol in oral administration (medicated feed route) were significantly higher than concentrations of florfenicol in bath route in plasma and ... Florfenicol pharmacokinetics following intravenous and oral administrations and its elimination after oral and bath administrations in common carp (Cyprinus carpio) #antibiotic.

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  • DOISerbia - Florfenicol - pharmacodynamic ...

    Florfenicol - pharmacodynamic, pharmacokinetics and clinical efficacy of oral formulations in domestic animals: A systematic review Ščuka Leon (Krka d.d., Novo mesto, Ljubljana, Slovenija) Porcine respiratory disease complex (PRDC) is a major economic problem for swine producers world-wide.

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  • Comparative absorption of curcumin formulations ...

    2014-1-24 · The population pharmacokinetics following the oral administration of the curcumin formulations were assessed by a Non-linear Mixed Effects Model using SPSS 21.0 (SPSS Inc., Chicago, IL). All plasma concentrations were log-transformed by use of natural logarithms and analyzed for meeting assumptions before proceeding with analysis.

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  • Guidance Document: Conduct and Analysis of

    2012-2-8 · Comparative bioavailability studies should be conducted in accordance with generally accepted clinical practices that are designed to ensure the protection of the rights, safety and well-being of subjects and the good clinical practices referred to in Division 5 of the Regulations and described in the International Conference on Harmonisation (ICH) Guidance (Topic E6) on Good Clinical Practice.

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  • Distribution, pharmacokinetics and primary

    The current study aimed to develop a rapid, robust and adequately sensitive method for simultaneous determination of the concentration of tramadol and its active metabolites in zebrafish. The pharmacokinetic and elimination pattern of tramadol and its major phase I metabolites following oral or intramuscular administration in zebrafish tissues was achieved using electrospray ionization ...

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  • Comparative Efficacy of MS-222 (Tricaine

    Abstract . Tricaine methanesulfonate (MS-222) is the only U.S. FDA approved anesthetic for use in food fish. It requires a 21 day withdrawal period in food fish prior to human consumption, and there is evidence that chronic exposure in fish, amphibians, and humans can cause reversible retinal deficits.

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  • A comparative study of texture coarseness measures ...

    A comparative study of texture coarseness measures (English) Chamorro-Martinez, J. Martinez-Jimenez, P. New search ... Determination of the method of drawing of prehistoric wall-paintings via original methods of pattern recognition and image analysis. Rousopoulos, P. Arabadjis, ...

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  • Florfenicol - pharmacodynamic, pharmacokinetics and

    Pharmacodynamic, pharmacokinetics and clinical efficacy of florfenicol oral formulations in domestic animals were evaluated. For this purpose the systematic review and meta-analysis were done. In vitro efficacy of florfenicol showed that this drug is highly effective …

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  • (PDF) Pharmacokinetics of florfenicol in cod Gadus

    Pharmacokinetics of florfenicol in cod Gadus morhua and in vitro antibacterial activity against Vibrio anguillarum. Ole Samuelsen. ø. Bergh. Ole Samuelsen. ø. Bergh. Related Papers. Efficacy of orally administered flumequine in the treatment of vibriosis caused by …

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  • Florfenicol for Chickens and Ducks - PoultryDVM

    Wang, Xiao, et al. Florfenicol causes excessive lipid peroxidation and apoptosis induced renal injury in broilers Ecotoxicology and Environmental Safety 207 (2021) Ismail, M., and Y. A. El-Kattan. Comparative pharmacokinetics of florfenicol in the chicken, pigeon and quail. British poultry science 50.1 (2009); hen, J., et al. Bioavailability and pharmacokinetics of florfenicol in broiler ...

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  • (PDF) Depletion of florfenicol and florfenicol amine ...

    Depletion of florfenicol and florfenicol amine residues in chicken eggs. Download. Depletion of florfenicol and florfenicol amine residues in chicken eggs. U. Sireli. A. Filazi. Begum Yurdakok. Fatma Aydin. A. Kucukosmanoglu. ... Comparative Pharmacokinetics of Gentamicin in Laying Hens.

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  • Pharmacodynamics of Ceftiofur Selected by Genomic

    2020-3-31 · The inhibitory effects of ceftiofur and florfenicol were determined against S. parauberis using a time-kill assay by the growth inhibition method. The bacterial incubation was performed with each tested antibiotic at concentrations of 0.5, 1, 2, and 4x MIC.

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  • FREEDOM OF INFORMATION SUMMARY - FDA

    b. Comparative Metabolism Study Comparative metabolism of florfenicol in the rat (the animal used in the toxicity tests) and in salmon was satisfactorily demonstrated by data in . the original approval of NADA 141-063 (florfenicol in cattle, FOI Summary dated May 31, 1996) and in …

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  • Comparative evaluation of methods for isolating small ...

    2020-3-25 · Comparative pharmacokinetics and preliminary pharmacodynamics evaluation of piscidin 1 against prv and pedv in rats. Frontiers in Chemistry, 6, 244-. 40. Lei Z, Liu Q, Qi Y, Yang B, Khaliq H, Xiong J, Moku GK, Ahmed S, Li K, Zhang H, Zhang W, Cao J, He Q.

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  • Distribution, pharmacokinetics and primary

    2021-2-10 · Small extracellular vesicles (sEVs) are nanosized vesicles involved in cell-to-cell communication. sEVs have been widely studied for clinical applications such as early detection of diseases and as therapeutics. Various methods for sEVs isolation are been using, but different methods may result in different qualities of sEVs and impact downstream analysis and applications.

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  • Guidance Document: Conduct and Analysis of

    Detection of two primary metabolites, M1 and M2, in brain tissue. Primary desmethyltramadol reference substances produced using the previously reported method (), and were analyzed by GC-MS. Compared with the aforementioned strategies to detect tramadol alone, the extraction method and analysis conditions were optimized for combined determination of tramadol and its primary metabolites.

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