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design of compound lincomycin hydrochloride soluble

  • Lincomycin hydrochloride | C18H35ClN2O6S - PubChem

    2007-10-19 · The invention relates to compound lincomycin hydrochloride soluble powder for poultry, which is characterized in that the powder is prepared by the even mixing of the following components in weight portion: 10 to 25 portions of lincomycin hydrochloride, 5 to 20 portions of tylosin phosphate, 5 to 15 portions of sulfadiazine sodium, and 40 to 80 portions of glucose.

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  • Compound lincomycin hydrochloride soluble powder

    Lincomycin hydrochloride is freely soluble in water; soluble in dimethylformamide and very slightly soluble in acetone. Function. It is mainly used for the treatment of infections caused by Gram-positive bacteria in particular the various penicillin-resistant Gram-positive bacteria , the poultry respiratory disease caused by Mycoplasma, swine ...

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  • Lincomycin hydrochloride monohydrate |

    Lincomycin hydrochloride Drug Entry Lincomycin. Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium Streptomyces lincolnensis in Lincoln, Nebraska. 2 Clinical use of lincomycin has largely been superseded by its semisynthetic derivative clindamycin due to its higher efficacy and a wider range of susceptible organisms, though lincomycin remains in use. 1,2

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  • China Lincomycin Pharmaceutical Lincomycin

    Lincomycin hydrochloride . E. Pharmacological Category: Antimicrobial . F. Dosage Form(s): Water soluble powder . G. Amount of Active Ingredient(s): 192 grams/bottle . H. How Supplied: 16.92 oz (480 gm) bottles . I. How Dispensed: Over-the-counter (OTC) J. Dosage(s): 100 mg per hive weekly for 3 weeks . K. Route(s) of Administration:

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  • Lincomycin hydrochloride | DrugBank Online

    absortion peak of Lincomycin hydrochloride is at 2400cm-1; Figure 3 and Figure 4 shows that: the inclusion compound disappeared at the maximum absorption peak in 2400cm-1, which indicating that lincomycin hydrochloride has been inclused by β- cyclodextrin. Figure 1. Lincomycin hydrochloride Figure 2. β-cyclodextrin Figure 3.

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  • FREEDOM OF INFORMATION SUMMARY - FDA

    1998-12-31 · The method was applied to the assay of different formulations of lincomycin hydrochloride. Lincomycin hydrochloride Ph. Eur. CRS was used as a standard. Replicate injections (n=3) of replicate sampling (n=2) were carried out in each case. Results of the assay are presented in Table 3. Assay of the samples yields good precision for the major component.

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  • Preparation of Lincomycin β Cyclodextrin Complex by ...

    Clindamycin (7-chloro-lincomycin) hydrochloride is a semisynthetic lincosamide antibiotic derivative of lincomycin [ L0166] to replace the 7-hydroxy group with a chlorine atom with inversion of chirality. Clindamycin is usually more active than lincomycin, in particular against anaerobic bacteria.

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  • Liquid chromatographic method for separation of

    2019-9-10 · The water-soluble prodrug presented a rapid release of the parent compound probably due the presence of the polar and protonable piperazine moiety. The neuroprotective biochemical profile was also performed in vitro and in cell-based assays, revealing a strong cytoprotective effect against cellular damage induced by Αβ ( Pisani et al., 2017 ).

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  • Lincomycin + Spectinomycin Water Soluble

    1998-12-31 · In developing this procedure the most difficult compounds to separate were the epimers, lincomycin and 7-epilincomycin. They differ structurally only in the configuration of the hydroxyl and hydrogen in the 7 position ().The methods described in the USP for lincomycin hydrochloride and for clindamycin hydrochloride and the Ph. Eur. method for clindamycin phosphate ester were examined …

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  • Liquid chromatographic method for separation of

    Clindamycin (7-chloro-lincomycin) hydrochloride is a semisynthetic lincosamide antibiotic derivative of lincomycin [ L0166] to replace the 7-hydroxy group with a chlorine atom with inversion of chirality. Clindamycin is usually more active than lincomycin, in particular against anaerobic bacteria.

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  • Clindamycin Hydrochloride 58207-19-5 | Tokyo

    Lincomycin Hydrochloride/ An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

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  • LINCOMYCIN HYDROCHLORIDE - Uses, DMF, Dossier ...

    Design of a Novel Nucleus-Targeted NLS-KALA-SA Nanocarrier to Delivery Poorly Water-Soluble Anti-Tumor Drug for Lung Cancer Treatment J Pharm Sci . 2021 Jun;110(6):2432-2441. doi: 10.1016/j.xphs.2020.12.034.

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  • Design of a Novel Nucleus-Targeted NLS-KALA-SA

    2019-8-31 · Surprisingly, compound 3 (method I) could not be obtained due to the cleavage of the C–C double bond in the course of the reaction followed by extensive destruction of the heterocyclic fragment. Variation of the reaction conditions, e.g., reduction of the reaction temperature and time, changing the ratio of the reactants and addition of NaI as a catalyst, did not suppress this decomposition ...

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  • Design, synthesis and investigation of water-soluble

    Design and evaluation of compound metformin ... A simple elementary osmotic pump (EOP) system that could deliver metformin hydrochloride (MT) ... both highly and poorly water-soluble drugs are ...

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  • Design and evaluation of compound metformin/glipizide ...

    2018-11-30 · commercially available 4,4-piperidinediol hydrochloride (1) with a benzyloxycarbonyl (Cbz) group to obtain 2. This compound was allowed to react with 1,4-dioxa-8-aza-spiro-[4.5]decane (3) in the presence of triacetoxyborohydride to afford piperidinopiperidin-4-one 4 diprotected with a cyclic ketal and a Cbz group.[9] Compound 4 led to two further

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  • Synthesis and Conformational Study of Water-Soluble,

    2016-1-6 · Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents. Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States.

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  • Design, synthesis, and biological evaluation of water ...

    2017-1-11 · A novel racemic compound of pioglitazone hydrochloride is discovered 17 years after the FDA approval of the conglomerate. The racemic compound shows a lower dissolution rate than the conglomerate in simulated gastric fluid at room temperature and is more thermodynamically stable as evidenced by solubility measurements. Slurry transformation of a mixture of the two forms converts …

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  • Clindamycin Hydrochloride | CAS 21462-39-5 | SCBT -

    2020-1-22 · Soluble in water, alcohol and DMF. Storage : Store at -20° C ... Clindamycin Hydrochloride (CAS 21462-39-5) Product Citations ... It's a semi-synthetic antibiotic and produced by the chlorination of Lincomycin while Lincomycin is produced by fermentation of Streptomyces lincolnensis mutant strain.

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  • Design and evaluation of novel barrier layer

    Context: Venlafaxine Hydrochloride (VH) is a highly soluble and highly permeable antidepressant compound. Thus controlling VH release from tablet dosage form over a prolonged period is a challenge. Objective: The objective of this work was to study the effect of various barrier layer formulation compositions, its orientations and manufacturing technology on release profile of highly soluble VH.

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  • Dilute solution properties of clindamycin 2-palmitate ...

    Europe PMC is an archive of life sciences journal literature. Clindamycin 2-palmitate hydrochloride forms micelles in aqueous solution at concentrations above 2-2 X 10(-3) M. Dilution of micellar solutions of the drug to concentrations less than 2-0 X 10(-3) M produces turbid systems.

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  • Design, synthesis and investigation of water-soluble

    2019-8-31 · Surprisingly, compound 3 (method I) could not be obtained due to the cleavage of the C–C double bond in the course of the reaction followed by extensive destruction of the heterocyclic fragment. Variation of the reaction conditions, e.g., reduction of the reaction temperature and time, changing the ratio of the reactants and addition of NaI as a catalyst, did not suppress this decomposition ...

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  • Design and evaluation of compound

    2010-2-18 · In general, both highly and poorly water‐soluble drugs are not good candidates for elementary osmotic delivery. However, MT is a highly soluble drug with a high dose (500 mg) while GZ is a water‐insoluble drug with a low dose (5 mg) so it is a great challenge to pharmacists to provide satisfactory extended release of MT and GZ.

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  • Design, synthesis, and biological evaluation of water ...

    2016-3-1 · 1. Bioorg Med Chem. 2016 Mar 1;24(5):938-956. doi: 10.1016/j.bmc.2016.01.007. Epub 2016 Jan 6. Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and …

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  • Carbonic anhydrase inhibitors: synthesis of water

    This new compound is quite water soluble as hydrochloride salt, behaves as a strong CA II inhibitor, and fared better than the parent molecule in lowering IOP in experimental animals. Thus, the tail conferring water solubility to such an enzyme inhibitor is more important for its topical activity as antiglaucoma drug than the heterocyclic ...

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  • Formulation Optimization of Selective Laser Sintering

    2020-8-13 · The aims of the current study were to develop and evaluate clindamycin palmitate hydrochloride (CPH) 3D-printed tablets (printlets) manufactured by selective laser sintering (SLS). Optimization of the formulation was performed by studying the effect of formulation and process factors on critical quality attributes of the printlets. The independent factors studied were laser scanning speed ...

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  • Soil Behaviour of the Veterinary Drugs Lincomycin ...

    Lincomycin, monensin, and roxarsone are commonly used veterinary drugs. This study investigated their behaviours in different soils and their toxic effects on environmental organisms. Sorption and mobility analyses were performed to detect the migration capacity of drugs in soils. Toxic effects were evaluated by inhibition or acute toxicity tests on six organism species: algae, plants, daphnia ...

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  • Tris (2-carboxyethyl) phosphine hydrochloride (TCEP ...

    Tris(2-carboxyethyl)phosphine hydrochloride (commonly known as TCEP or TCEP-HCl), product number 10014, is a water-soluble, stable, odorless, irreversible reducing agent that cleaves disulfide bonds specifically, rapidly reducing them to thiols. Read More TCEP has several advantages over disulfide reducing agents such as dithiothreitol (DTT) and β-mercaptoethanol.

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  • Design and evaluation of novel barrier layer

    Context: Venlafaxine Hydrochloride (VH) is a highly soluble and highly permeable antidepressant compound. Thus controlling VH release from tablet dosage form over a prolonged period is a challenge. Objective: The objective of this work was to study the effect of various barrier layer formulation compositions, its orientations and manufacturing technology on release profile of highly soluble VH.

    Get Price
  • Design, synthesis, and biological evaluation of water ...

    2016-3-1 · 1. Bioorg Med Chem. 2016 Mar 1;24(5):938-956. doi: 10.1016/j.bmc.2016.01.007. Epub 2016 Jan 6. Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and …

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  • Design and Synthesis of a New Soluble Natural β

    Harmine is a natural β-carboline compound showing several biological activities, including antiproliferative properties, but this soluble natural molecule lacks selectivity. Harmine derivatives were reported to overcome this problem, but they are usually poorly soluble. Here, we designed and synthesized a new 2, 7, 9-trisubstituted molecule (1-methyl-7-(3-methylbutoxy)-9-propyl-2-[(pyridin-2 ...

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  • Rational design of a water-soluble NIR AIEgen, and its ...

    Rational design of a water-soluble NIR AIEgen, and its application in ultrafast wash-free cellular imaging and photodynamic cancer cell ablation† Dong Wang, ad Huifang Su, c Ryan T. K. Kwok, a Xianglong Hu,*ab Hang Zou,a Qianxin Luo,a Michelle M. S. Lee, a Wenhan Xu, …

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  • DESIGN OF NON-FLUOROUS CO SOLUBLE COMPOUNDS

    2016-5-10 · Gelest. Neither was soluble in CO2 and copolymers with lesser degrees of phenyl methyl siloxane were not available. An attempt was also made to design small molecules as thickeners. The first CO2 soluble non-fluorous, acetylated hydrogen-binding compound and the first CO2 soluble non-fluorous dendrimer were synthesized.

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  • Design and evaluation of compound

    2005-7-1 · A simple elementary osmotic pump (EOP) system that could deliver metformin hydrochloride (MT) and glipizide (GZ) simultaneously for extended periods of time was developed in order to reduce the problems associated with multidrug therapy of type 2 non‐insulin‐dependent diabetes mellitus. In general, both highly and poorly water‐soluble drugs are not good candidates for elementary osmotic ...

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  • Carbonic anhydrase inhibitors: synthesis of water

    This new compound is quite water soluble as hydrochloride salt, behaves as a strong CA II inhibitor, and fared better than the parent molecule in lowering IOP in experimental animals. Thus, the tail conferring water solubility to such an enzyme inhibitor is more important for its topical activity as antiglaucoma drug than the heterocyclic ...

    Get Price
  • Formulation Optimization of Selective Laser Sintering

    2020-8-13 · The aims of the current study were to develop and evaluate clindamycin palmitate hydrochloride (CPH) 3D-printed tablets (printlets) manufactured by selective laser sintering (SLS). Optimization of the formulation was performed by studying the effect of formulation and process factors on critical quality attributes of the printlets. The independent factors studied were laser scanning speed ...

    Get Price
  • Characterization of Hydrochloride and Tannate Salts

    2008-5-10 · Proper characterization is an important aspect of any dosage form design. The objective of this work was to characterize tannate salt and hydrochloride salt of diphenhydramine. As a part of characterization studies, Differential scanning calorimetry was used to investigate thermal effects and nature of salts, supported by X-ray powder diffraction.

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  • Soil Behaviour of the Veterinary Drugs Lincomycin ...

    Lincomycin, monensin, and roxarsone are commonly used veterinary drugs. This study investigated their behaviours in different soils and their toxic effects on environmental organisms. Sorption and mobility analyses were performed to detect the migration capacity of drugs in soils. Toxic effects were evaluated by inhibition or acute toxicity tests on six organism species: algae, plants, daphnia ...

    Get Price
  • Design of a Water Soluble Fluorescent 3-Hydroxy-4 ...

    2016-6-29 · The compound is water soluble but in order to keep the stock solutions for a longer period of time the compound was dissolved in DMSO and then dissolved in water to be further used. In Fig. 4 the normalized absorption and emission spectra of D-3,4-HPO in water at pH = 7.0 and 25 °C is depicted.

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  • Synthesis and SARs of novel lincomycin derivatives

    2017-11-1 · Compound 15 (1.15 g, 4.04 mmol), 56 (2.02 g, 4.85 mmol), 1-hydroxybenzotriazole (0.819 g, 6.06 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.16 g, 6.06 mmol) in …

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  • Design and synthesis of novel soluble 2,5

    Design and synthesis of novel soluble 2,5-diketopiperazine derivatives as potential anticancer agents. by Shengrong Liao, Xiaochu Qin, Ding Li, Zhengchao Tu, Jinsheng Li, Xuefeng Zhou, Junfeng Wang, Bin Yang, Xiuping Lin, Juan Liu, Xianwen Yang, Yonghong Liu. European journal of medicinal chemistry. Read more related scholarly scientific articles and abstracts.

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  • Design and evaluation of 1- and 3-layer matrices of ...

    2005-12-7 · The present study was performed to design oral controlled delivery systems for the water-soluble drug, verapamil hydrochloride, using natural and semisynthetic polymers as carriers in the forms of 1- and 3-layer matrix tablets. Verapamil hydrochloride 1-layer matrix tablets containing hydroxypropylmethylcellulose, tragacanth, and acacia either ...

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  • Novel Water-Soluble Substituted Pyrrolo[3,2- d ...

    2012-7-20 · The compound tested in the NCI 60 cell line is a 2-digit nanomolar (GI50) inhibitor of 8 tumor cell lines. We have identified substituted pyrrolo[3,2-d]pyrimidines that are water-soluble colchicine site microtubule depolymerizing agents. These compounds serve as leads for further optimization.

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  • Minimalist design of water-soluble cross-β

    2010-2-23 · Cross-β Design Using Minimalist Motifs. The rapid growth in the number of structures of fibril-forming peptides obtained by x-ray crystallography and solid-state NMR spectroscopy provides a wealth of common characteristics that could be applied towards the rational design of the cross-β motif in globular proteins (5–9, 27, 28).We envisioned that a water-soluble cross-β architecture could ...

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  • Sulfaquinoxaline Sodium (10%,20%,70%) Soluble

    2021-3-16 · e ester component was found to be the main culprit. To exclude this potential risk, we designed 2 amino acid propofol prodrugs (HX0969-Gly-F3, HX0969-Ala-HCl) based on the lead compound (HX0969) by introducing the amino acid group into the structures of the propofol prodrugs. We hypothesized that the improved propofol prodrugs could not only eliminate those adverse effects but …

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  • Frontiers | New Concept of the Biosynthesis of 4-Alkyl

    2020-4-1 · Benefits of Lipid-based Delivery Systems in Poorly Soluble Drugs. A growing number of pharmaceutical companies’ drug pipelines are being filled with water-insoluble (BCS II/IV) or low permeable (BCS III/IV) therapeutic entities. Lipid-based drug delivery systems have become an important tool for the formulation development of those compounds.

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  • Lincomycin hydrochloride | 859-18-7

    Visit ChemicalBook To find more Lincomycin hydrochloride(859-18-7) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Lincomycin hydrochloride(859-18-7).

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  • DailyMed - CLINDAMYCIN PALMITATE

    Clindamycin palmitate hydrochloride is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid. Clindamycin is a semisynthetic antibiotic produced by a 7 (S)-chloro-substitution of the 7 (R)-hydroxyl group of the parent compound lincomycin. The structural formula is represented below:

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  • Synthesis and SARs of novel lincomycin derivatives

    2017-11-1 · Compound 15 (1.15 g, 4.04 mmol), 56 (2.02 g, 4.85 mmol), 1-hydroxybenzotriazole (0.819 g, 6.06 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.16 g, 6.06 mmol) in …

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  • Cleocin Phosphate (clindamycin injection, USP) and ...

    2009-3-31 · water soluble ester of clindamycin and phosphoric acid. Each mL contains the equivalent of 150 mg clindamycin, 0.5 mg disodium edetate and 9.45 mg benzyl alcohol added as preservative in each mL. Clindamycin is a semisynthetic antibiotic produced by a 7(S)­ chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin. 1

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  • Design and evaluation of 1- and 3-layer matrices of ...

    2005-12-7 · The present study was performed to design oral controlled delivery systems for the water-soluble drug, verapamil hydrochloride, using natural and semisynthetic polymers as carriers in the forms of 1- and 3-layer matrix tablets. Verapamil hydrochloride 1-layer matrix tablets containing hydroxypropylmethylcellulose, tragacanth, and acacia either ...

    Get Price
  • Design, Synthesis, and Biological Activity of 1,3 ...

    2011-10-24 · Design, Synthesis, and Biological Activity of 1,3-Disubstituted Ureas as Potent Inhibitors of the Soluble Epoxide Hydrolase of Increased Water Solubility In-Hae Kim, Christophe Morisseau, Takaho Watanabe, and Bruce D. Hammock* Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue,

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  • An Efficient Synthesis of Milnacipran Hydrochloride

    2017-3-20 · An efficient synthesis of milnacipran hydrochloride has been accomplished. The important application of this paper is the reductive amination of aldehyde to primary amine with water soluble reagents. This method provides a high yield of primary amine as the major product, reduces the number of steps, and discourages by-products.

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  • An Improved Design of Water-Soluble Propofol

    2021-3-16 · e ester component was found to be the main culprit. To exclude this potential risk, we designed 2 amino acid propofol prodrugs (HX0969-Gly-F3, HX0969-Ala-HCl) based on the lead compound (HX0969) by introducing the amino acid group into the structures of the propofol prodrugs. We hypothesized that the improved propofol prodrugs could not only eliminate those adverse effects but …

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  • (PDF) The design and discovery of water soluble 4 ...

    The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents. cristina rohena. Anja Bastian + 9 More. cristina rohena. Anja Bastian. …

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  • Development and Characterization of Nanoparticles

    2014-1-27 · Gemcitabine (2,2-difluorodeoxycytidine) is a deoxycytidine analog, currently being used as a first-choice drug in pancreatic metastatic cancer. Gemcitabine is administered weekly as 30-minute infusion with starting dose ranging from 800 to 1250 mg/m 2 . The aim of the present work was to develop starch nanoparticles (NPs) for the delivery of gemcitabine hydrochloride that could reduce its dose ...

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  • JDZ Biology

    Lincomycin Hydrochloride Soluble Powder Doxycycline Hyclate Soluble Powder Vitamin C Soluble Powder ... Compound Sulfamonomethoxine Sodium Powder Flunixin Meglumine Granules Fenbendazole Powder All our Products. Probiotic Material Growth Magic Peptide ...

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  • Design, Synthesis, and Biological Activity of 1,3 ...

    2011-10-24 · Design, Synthesis, and Biological Activity of 1,3-Disubstituted Ureas as Potent Inhibitors of the Soluble Epoxide Hydrolase of Increased Water Solubility In-Hae Kim, Christophe Morisseau, Takaho Watanabe, and Bruce D. Hammock* Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue,

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  • Veterinary - China Veterinary Medicine,

    View reliable Veterinary manufacturers on Made-in-China.com. This category presents Veterinary Medicine, Oxytetracycline Injection, from China Veterinary suppliers to global buyers., page 4

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  • Shijiazhuang Fengqiang Animal Pharmaceutical Co.,ltd.

    Shijiazhuang Fengqiang Animal Pharmaceutical Co.,ltd. Shijiazhuang City Fengqiang Veterinary Pharmaceutical Co., Ltd.£¬established in May ,1998, is one Hi-tech joint-stock company engaging in the R&D, producing and marketing of veterinary pharmaceutical and healthy products. Fengqiang, located in the Shangzhuang Industrial Zone of ...

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  • Inhibition of Peroxidase Activity of Cytochrome c: De

    2015-9-1 · Cytochrome c (cyt c ) release from mitochondria is accepted to be the point of no return for eliciting a cascade of interactions that lead to apoptosis. A strategy for containing sustained apoptosis is to reduce the mitochondrial permeability pore opening. Pore opening is enhanced by peroxidase activity of cyt c gained upon its complexation with cardiolipin in the presence of reactive oxygen ...

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  • Book chapters: 'Organic compound. eng' – Grafiati

    國立臺灣大學. 環境工程學研究所. 87. For volatile organic compound (VOCs),including lower molecular weight hydrocarbons, solvents and other semi-volatile organic compound contaminated vadose zone, bioventing is a better soil remediation method than some other on …

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  • IND 2021 « New Drug Approvals

    2017-3-27 · It is freely soluble in water, soluble in methanol, slightly soluble in ethanol, and insoluble in chloroform and ether. The empirical formula is C6H18N4·2HCI with a molecular weight of 219.2. The structural formula is: NH 2 (CH 2) 2 NH(CH 2) 2 NH(CH 2) 2 NH 2 •2HCI. Trientine hydrochloride is a chelating compound for removal of excess copper ...

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  • SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR

    The present invention provides a compound having the structure: wherein; R 1, R 2, R 3, R 4, and R 5 are each independently H, halogen, CF 3 or C 1-C 4 alkyl, . wherein two or more of R 1, R 2, R 3, R 4, or R 5 are other than H;; R 6 is H, OH, or halogen; and; B is a substituted or unsubstituted heterobicycle,

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  • Pharmaceutics | Free Full-Text | Novel Non

    Choline kinase alpha (CHKA) is a promising target for the development of cancer therapeutics. We have previously reported ICL-CCIC-0019, a potent CHKA inhibitor with high cellular activity but with some unfavorable pharmacological properties. In this work, we present an active analogue of ICL-CCIC-0019 bearing a piperazine handle (CK146) to facilitate further structural elaboration of the ...

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  • US Patent for Diacylglycerol acyl transferase 2

    Water-soluble polymers suitable for use in the solid amorphous dispersions should be inert, in the sense that they do not chemically react with the poorly soluble compound in an adverse manner, are pharmaceutically acceptable, and have at least some solubility in aqueous solution at physiologically relevant pHs (e.g. 1-8).

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  • Lincomycin hydrochloride | 859-18-7

    Visit ChemicalBook To find more Lincomycin hydrochloride(859-18-7) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Lincomycin hydrochloride(859-18-7).

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  • Synthesis and SARs of novel lincomycin derivatives

    2017-11-1 · Compound 15 (1.15 g, 4.04 mmol), 56 (2.02 g, 4.85 mmol), 1-hydroxybenzotriazole (0.819 g, 6.06 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.16 g, 6.06 mmol) in …

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  • Lincomycin. Medical search

    2021-7-7 · Lincomycin - Uses, Dosage, Side Effects, Price, Composition | Practo. Lincomycin is an antibiotic which is used in the treatment of infections caused by bacteria like streptococci, pneumococci, and staphylococci. It should be used only in cases where other medicines are less effective.

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  • BASIC CONCEPTS AND APPLICATION OF PRODRUG DESIGN

    2020-5-17 · Eg: chloramphenicol palmitate is the sparingly soluble of prodrug of chloramphenicol, which is practically tasteless due to its low aqueous solubility, as well as it is hydrolysed to active chloramphenicol by the action of pancreatic lipase. Eg:Ethyl mercaptan has a boiling point of 25ºC and a strong disagreeable odour.

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  • An Improved Design of Water-Soluble Propofol

    2021-3-16 · e ester component was found to be the main culprit. To exclude this potential risk, we designed 2 amino acid propofol prodrugs (HX0969-Gly-F3, HX0969-Ala-HCl) based on the lead compound (HX0969) by introducing the amino acid group into the structures of the propofol prodrugs. We hypothesized that the improved propofol prodrugs could not only eliminate those adverse effects but …

    Get Price
  • Synthesis and characterization of fourth generation ...

    2018-7-5 · In this work, we report the design and realization of two versatile successful procedures to decorate a fourth generation polyester-based dendrimer matrix with a mixture of four different amino acids. The hydrochloride dendrimers achieved after removal of protecting groups were characterized by a core-shell structure. They harmonized a not ...

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  • ANSWERS TO QUESTIONS Chapter 2: Drug Design and ...

    2005-5-31 · Chapter 2: Drug Design and Relationship of Functional Groups to Pharmacologic Activity Question #1 Answer: At pH 2.0 amobarbital is in the acid or unionized form (100%) since the pH is 6 log units below the pKa of the compound. At a pH of 5.5 the acid form still predominates (99.7%).

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  • SOLUBILITY RULES

    2002-3-22 · SOLUBILITY RULES. Most of the precipitation reactions that we will deal with involve aqueous salt solutions. Remember salts are compounds which consist of metal cations like Na +, Ca 2+, Cu 2+ (or the one nonmetal molecular ion that we have discussed, ammonium - NH 4 +) ionically bonded to nonmetal anions such as Cl-, (including molecular anions such as hydroxide - OH-, sulfate - SO 4 2 ...

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  • A biocompatible poly(amidoamine) (PAMAM)

    2020-6-19 · In pursuit of the design of novel anticancer agents, herein, we present efficient and facile methods for the preparation of the first PAMAM G1.0 dendrimer octa-substituted with α-cyclodextrin (octa-αCD-PAMAM) and a novel DOX*HCl prodrug, namely ferrocenyl ester of doxorubicin hydrochloride (Fc–COO–DOX*HCl).

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  • GUCY1A2 Gene - GeneCards | GCYA2 Protein | GCYA2

    GUCY1A2 (Guanylate Cyclase 1 Soluble Subunit Alpha 2) is a Protein Coding gene. Diseases associated with GUCY1A2 include Nemaline Myopathy 7.Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling in Gap Junctions.Gene Ontology (GO) annotations related to this gene include GTP binding and phosphorus-oxygen lyase activity.

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  • Rational design of highly potent broad-spectrum ...

    2020-11-6 · There is a great need for antiviral drugs to treat enterovirus and rhinovirus infections, which can be severe and occasionally life-threatening. This study describes novel small molecule inhibitors that target a broad spectrum of clinically relevant enterovirus species; a common mechanism of resistance development revealed the target to be a highly conserved binding pocket in the viral ...

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  • Main trends in the design of semi-synthetic antibiotics

    2020-3-1 · Main trends in the design of semi-synthetic antibiotics of a new generation. 1 Gause Institute of New Antibiotics, ul. Bolshaya Pirogovskaya 11, 119021 Moscow, Russian Federation. 2 Russian State Agrarian University – Moscow Timiryazev Agricultural Academy, ul. Timiryazevskaya 49, 127550 Moscow, Russian Federation.

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  • BASIC CONCEPTS AND APPLICATION OF PRODRUG DESIGN

    2020-5-17 · Eg: chloramphenicol palmitate is the sparingly soluble of prodrug of chloramphenicol, which is practically tasteless due to its low aqueous solubility, as well as it is hydrolysed to active chloramphenicol by the action of pancreatic lipase. Eg:Ethyl mercaptan has a boiling point of 25ºC and a strong disagreeable odour.

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  • COMPOUND HAVING AFFINITY SUBSTANCE TO

    The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I): A-L-B-R (I) wherein A is an affinity substance ...

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  • Technologies to Improve the Solubility, Dissolution

    2017-12-4 · Combinatorial chemistry, computational molecular modeling and high throughput screening in drug discovery have significantly increased the number of poorly soluble drugs. About 40% of drugs developed in the past and about 90% of the drugs in development are poorly soluble drugs. When administered orally, a drug has to first dissolve in gastrointestinal fluids before it can be absorbed in to ...

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  • Clozapine N-oxide (CNO) dihydrochloride (water

    2016-1-18 · The soluble fractions were divided into smaller (50 μl) aliquots and heated individually at different temperatures (26.0, 48.0, 51.9, 55.8, 60.0 and 64.6 °C) for 5 min with a C1000TM thermal ...

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  • Small-molecule targeting of a diapophytoene

    2021-6-25 · Engineering ToolBox - Resources, Tools and Basic Information for Engineering and Design of Technical Applications! - search is the most efficient way to navigate the Engineering ToolBox! Guidelines or solubility rules to predict whether or not a given ionic compound is soluble …

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  • Solubility guidelines for ionic compounds in water

    The words soluble and insoluble are qualitative, not quantitative. We will use 3% as a determination of solubility. If your compound is not completely soluble as a 3% solution, you can call it insoluble or partially soluble. Moreover, some compounds which are not soluble at room temperature, may be soluble at higher temperature.

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  • 8: Identification of Unknowns (Experiment) -

    2021-6-25 · Salts are nothing but ionic compounds. Most ionic compounds or salts tend to be soluble in water because water contains polar molecules, the positive end of the water molecules pulls on the negative ion while the negative part of the water pulls the positive ion. This is how water dissolves salts

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  • Structure-Based Design and Characterization of Novel ...

    2005-1-4 · observed binding.22 Pteroic acid is poorly soluble and has limited value as a lead compound for the design of effective inhibitors and useful RIP antidotes. Energy calculations were used to investigate likely binding modes of other potential inhibitors, including tautomers * To whom correspondence should be addressed. Phone: (512) 471-3175.

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  • Lincomycin Biosynthesis Involves a Tyrosine

    2013-12-4 · The gene lmbB2 of the lincomycin biosynthetic gene cluster of Streptomyces lincolnensis ATCC 25466 was shown to code for an unusual tyrosine hydroxylating enzyme involved in the biosynthetic pathway of this clinically important antibiotic. LmbB2 was expressed in Escherichia coli, purified near to homogeneity and shown to convert tyrosine to 3,4-dihydroxyphenylalanine (DOPA).

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  • BASIC CONCEPTS AND APPLICATION OF PRODRUG DESIGN

    2020-5-17 · Eg: chloramphenicol palmitate is the sparingly soluble of prodrug of chloramphenicol, which is practically tasteless due to its low aqueous solubility, as well as it is hydrolysed to active chloramphenicol by the action of pancreatic lipase. Eg:Ethyl mercaptan has a boiling point of 25ºC and a strong disagreeable odour.

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  • S4CARLISLE DESIGN SERVICES OF

    2021-1-28 · Fat Soluble and Water Soluble A vitamin is either fat soluble or water soluble, depending on how it is absorbed and handled in the body. Fat-soluble vitamins need dietary fat to be properly absorbed, while water- soluble vitamins are absorbed with water. A D E K e Biotin othenic acid B 2 C Thiamin (B 1) vin (B 2) Niacin xine (B 6 ) Fat-soluble ...

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  • What is the Solubility of My Compound? Assessing ...

    2016-9-21 · Compound X is water soluble, but is more soluble in diethyl ether. Suppose the solubility of X in water is 2.0 g/100 mL, while its solubility in ether is 10.0 g/100 mL. If ether is added to the solution of water containing X, compound X will partition itself between the ether and the water based on …

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  • Exp 6 - Extraction

    2005-5-31 · Chapter 2: Drug Design and Relationship of Functional Groups to Pharmacologic Activity Question #1 Answer: At pH 2.0 amobarbital is in the acid or unionized form (100%) since the pH is 6 log units below the pKa of the compound. At a pH of 5.5 the acid form still predominates (99.7%).

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