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  • Suspected ciprofloxacin-induced hepatotoxicity

    Hepatotoxicity has been reported with other fluoroquinolone antibiotics, and there have been previous unpublished reports to the manufacturer of possible hepatotoxicity caused by ciprofloxacin. Conclusions: It is suggested that ciprofloxacin can cause severe hepatic injury and that healthcare providers should be aware of this possible adverse drug reaction.

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  • Hepatotoxicity from green tea: a review of the literature ...

    2021-6-27 · the manufacturer of Exolise (Arkopharma, Carros, France), a green tea extract containing high EGCG levels and marketedasaweightlosssupplement,withdrewthisproduct from the market owing to 13 cases of liver damage due to its consumption[www.afssaps.sante.fr]. The same product was also removed from the Spanish market because of other hepatotoxicity cases.

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  • Cytokines induce small intestine and liver injury after ...

    2010-8-9 · After 5 and 24 h induction of AKI, plasma, liver and small intestine TNF-α, IL-6 and IL-17A levels were measured with mouse-specific ELISA kits according to the manufacturer…

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  • The concentration of tumor necrosis factor-α determines ...

    2020-1-27 · Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine in disease pathogenesis such as liver injury, which governs development of the immune system, cell survival signaling pathways ...

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  • ELISA Kit for Tumor Necrosis Factor Related Apoptosis ...

    Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) were tested on 3 different plates, 8 replicates in each plate. CV(%) = SD/meanX100 Intra-Assay: CV10% Inter-Assay: CV12%

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  • Is toxoplasmosis a potential risk factor for liver ...

    2015-10-1 · All tests were performed following the instructions of the manufacturer. 2.4. Histopathology of percutaneous ultrasound guided liver biopsy. Liver biopsies were analysed after paraffin embedding. Five μm sections were obtained from chronic HCV group, for hematoxylin and eosin (H&E) and Masson's trichrome staining.

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  • Control of hepatocyte proliferation and survival by Fgf ...

    We used siRNA formulated into lipid nanoparticles, which allows an efficient knockdown in the liver after a single injection.14 The nanoparticles specifically target hepatocytes due to an apolipoprotein E-dependent mechanism of delivery.15–17 Recently, we demonstrated the usefulness of an siRNA approach to determine the role of β1-integrin in liver regeneration.18 Importantly, the knockdown was only efficient in hepatocytes, but not in non-parenchymal liver …

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  • Trail induces cell migration and invasion in apoptosis ...

    2005-5-25 · Rockford, IL) according to the manufacturer’s instructions. Nuclear protein extracts were screened for NF- B DNA binding activity using the Trans AM assay (Active Motif; Carlsbad, CA) employing the NF- B consensus binding motif 5 -GGGACTTTCC-3 nucleotide sequence and p65 antisera in a quantitative ELISA-like assay. Results

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  • Oral Phosphatidylcholine Improves Intestinal Barrier ...

    2021-5-20 · CCl 4-injured mice liver fibrosis and hPMSC transplantation. To induce liver fibrosis, 8-week-old C57BL/6 mice (20 ± 2 g) were intraperitoneally injected with CCl 4 (0.5 mL/kg body weight, dissolved in olive oil, 1:9; Sigma-Aldrich) twice a week for 6 weeks (n = 20). Five mice were sacrificed every 2 weeks for histopathological examination and liver function test.

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  • Control of hepatocyte proliferation and survival by Fgf ...

    Results siRNA-mediated knockdown of Fgfr4 severely affected liver regeneration due to impairment of hepatocyte proliferation combined with liver necrosis. Mechanistically, the proliferation defect resulted from inhibition of an Fgf15-Fgfr4-Stat3 signalling pathway, which is required for injury-induced expression of the Foxm1 transcription factor and subsequent cell cycle progression, …

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  • [Clinical experience of double plasma molecular absorption ...

    Objective: To evaluate the effect of the double plasma molecular adsorption system (DPMAS) with a combination of two hemoperfusion machines in treatment of liver failure. Methods: A retrospective analysis was conducted. The clinical data from 42 patients with liver failure admitted to Tianjin Second People's Hospital from September 2012 to September 2013 were enrolled.

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  • Trail induces cell migration and invasion in apoptosis ...

    2005-5-25 · Institutional Review Board. Archival liver specimens were obtained from patients who had undergone liver transplantation for PSC (N 15) and primary biliary cirrhosis (PBC; N 9) and surgical resection for CCA (N 11). Normal liver specimens were obtained from 12 liver biopsy samples of 5 living and 7 deceased liver transplant donors.

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  • Human adipose stem cell-derived extracellular nanovesicles ...

    2020-4-10 · 1. Introduction. Liver fibrosis is one of the major causes of morbidity and mortality worldwide. It is a chronic liver disease that arises from an excessive wound healing response caused by liver injury depending on underlying aetiologies—viral hepatitis, alcoholic hepatitis, nonalcoholic steatohepatitis, autoimmune liver diseases, and metabolic disorders [, , , , ].

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  • Is toxoplasmosis a potential risk factor for liver ...

    2015-10-1 · All tests were performed following the instructions of the manufacturer. 2.4. Histopathology of percutaneous ultrasound guided liver biopsy. Liver biopsies were analysed after paraffin embedding. Five μm sections were obtained from chronic HCV group, for hematoxylin and eosin (H&E) and Masson's trichrome staining.

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  • CIMZIA® (certolizumab pegol) | An FDA-Approved Biologic ...

    CIMZIA is a biologic treatment for multiple chronic inflammatory conditions. Learn more about treatments, important safety information, and if you're eligible for CIMZIA with 0 co-pay. See full prescribing information including boxed warning on serious infections.

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  • JCI - The pseudokinase MLKL mediates programmed ...

    2016-10-17 · The diagnosis of AIH was defined according to the guidelines of the European Association for the Study of Liver Disease and was based on compatible symptoms and signs of AIH, elevated ALT and AST, increased serum IgG, serological findings (elevated antinuclear antibodies, smooth muscle antibody, soluble liver antigen, or liver kidney/microsome ...

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  • Combinatory Effects of Cerium Dioxide Nanoparticles and ...

    2021-6-25 · severe liver toxicity and may even result in death [4]. The toxicity of APAP is caused via the generation of the reactive N-acetyl-p-benzoquinone imine (NAPQI) during phase I of hepatic biotransformation, followed by cell necrosis and/or apoptosis of the hepatocytes exposed [1]. The development of DILI may also be influenced by chemical ...

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  • VELCADE® (bortezomib) | Patient Information

    VELCADE treatment can cause nausea, vomiting, diarrhea, and constipation. If your symptoms are severe, your doctor may recommend IV fluids and/or medications. Low platelet counts (thrombocytopenia). VELCADE can cause low levels of platelets (clot-forming cells). If platelets become very low, there is an increased risk of bleeding.

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  • Deficiency of NALP3 Signaling Impairs Liver Regeneration ...

    2017-6-28 · Inflammatory response is required to proceed the optimal liver regeneration after liver injury. Recent reports demonstrated that inflammasomes are involved in the innate immune response. Several NOD-Like receptors (NLRs) participated in the formation of the inflammasomes. NACHT, LRR, and PYD domain-containing protein 3 (NALP3) belongs to the NLR families and …

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  • O-GlcNAc transferase suppresses necroptosis and liver

    2019-11-1 · Liver tissues were weighed and homogenized in assay diluent provided by the TNFA or IL-6 ELISA kit (BD Biosciences). Plasma samples were collected with heparin as anticoagulant, centrifuged at 1,000 g at 4°C, and stored at –80°C until measurement. Assays were performed according to the manufacturer’s protocol.

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  • Liver function tests - Mayo Clinic

    2019-6-13 · Liver function tests are blood tests used to help diagnose and monitor liver disease or damage. The tests measure the levels of certain enzymes and proteins in your blood.

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  • Ishak Scoring On Liver Histopathology | Medical Calculator

    The Ishak system is associated with good interobserver reliability if a deviance of one categorical level in each variable of the system is accepted as agreement. Compared to the Knodell system it provides more detailed information but is less reliable regarding fibrosis.

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  • HUMIRA® (adalimumab) | A Biologic Treatment Option

    2021-6-16 · Liver problems. Symptoms include feeling very tired, skin or eyes that look yellow, poor appetite or vomiting, and pain on the right side of your stomach (abdomen). These problems can lead to liver failure and death. Psoriasis (new or worsening). Symptoms include red scaly patches or raised bumps that are filled with pus.

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  • CIMZIA® (certolizumab pegol) | An FDA-Approved Biologic ...

    CIMZIA is a biologic treatment for multiple chronic inflammatory conditions. Learn more about treatments, important safety information, and if you're eligible for CIMZIA with 0 co-pay. See full prescribing information including boxed warning on serious infections.

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  • JCI - Hepatic neuregulin 4 signaling defines an endocrine ...

    2017-11-6 · Aberrantly elevated liver cell death is linked to activation of liver regeneration and wound repair program, resulting in persistent inflammation and liver fibrosis that increase risk for cirrhosis and liver cancer. Several forms of hepatocyte death have been observed in the liver, including apoptosis, necrosis, and necroptosis.

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  • JCI - The pseudokinase MLKL mediates programmed ...

    2016-10-17 · The diagnosis of AIH was defined according to the guidelines of the European Association for the Study of Liver Disease and was based on compatible symptoms and signs of AIH, elevated ALT and AST, increased serum IgG, serological findings (elevated antinuclear antibodies, smooth muscle antibody, soluble liver antigen, or liver kidney/microsome ...

    Get Price
  • VELCADE® (bortezomib) | Patient Information

    VELCADE treatment can cause nausea, vomiting, diarrhea, and constipation. If your symptoms are severe, your doctor may recommend IV fluids and/or medications. Low platelet counts (thrombocytopenia). VELCADE can cause low levels of platelets (clot-forming cells). If platelets become very low, there is an increased risk of bleeding.

    Get Price
  • Frontiers | Therapeutic Role of Inducible Nitric Oxide ...

    2020-10-29 · BackgroundAcetaminophen (APAP) overdose is one of the major etiologies of liver failure. Hepatocyte necrosis induced by toxic metabolites of APAP can activate proinflammatory responses, including elastase-expressing neutrophils, to exacerbate liver injury. Myeloid-derived suppressor cells (MDSCs) increased in inflammation can inhibit proinflammatory responses.

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  • Word of Caution on Angiogenesis Inhibitor for Liver Cancer ...

    2021-3-8 · Liver cancer is the sixth most common cancer worldwide, and the fourth leading cause of cancer-related death globally. HCC develops in 85-95% of patients with cirrhosis of the liver, at a …

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  • LIVER Randomised controlled trial comparing percutaneous ...

    necrosis, the need for fewer treatment sessions,8 and a significantly higher local recurrence free survival.9 However, there have been no randomised controlled trials comparing these three treatments in terms of complications, complete tumour necrosis, local tumour recurrence, new tumour recurrence, overall survival, and cancer free survival. This

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  • Mechanical homeostasis of liver sinusoid is involved in ...

    2021-4-7 · Acute liver regeneration is induced by an increase in portal flow. a Schematic of the small orthotopic liver transplantation (s-OLT) model. The donor liver was harvested from 5-week-old Wistar rats and transplanted to 15-week-old Wistar rats. b Blood flow rate in the portal vein of donors and recipients (n = 3 for each age). Data are presented ...

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  • HUMIRA® (adalimumab) | A Biologic Treatment Option

    2021-6-16 · Liver problems. Symptoms include feeling very tired, skin or eyes that look yellow, poor appetite or vomiting, and pain on the right side of your stomach (abdomen). These problems can lead to liver failure and death. Psoriasis (new or worsening). Symptoms include red scaly patches or raised bumps that are filled with pus.

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  • Apolipoprotein A5 alleviates LPS d -GalN-induced ...

    2019-5-10 · Fulminant liver failure (FHF) is a serious clinical problem and liver transplantation is the major intervention. But the overall survival rate of FHF is low owing to the donated organ shortage. Apolipoprotein A-V (ApoA5) is a regulator of triglyceride metabolism and has been reported to act as a predictor for remnant liver growth after preoperative portal vein embolization and liver …

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  • Evaluation of tumor necrosis factor (TNF)-α mRNA ...

    Crohn's disease (CD) and ulcerative colitis (UC) are types of chronic inflammatory bowel disease (IBD) of which the actual causes remain unknown. Emerging data indicate that alterations in cytokine synthesis may be involved in IBD pathogenesis. The aim of the present study was to determine whether the tumor necrosis factor (TNF)‑α mRNA expression level and rs1799964 …

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  • Effects of supplementation with main coffee components ...

    2021-4-10 · Non-alcoholic fatty liver disease (NAFLD) is much more frequent and more severe, including cirrhosis, hepatocellular carcinoma in patients with type 2 diabetes. Coffee is a complex beverage with hundreds of compounds whereas caffeine and chlorogenic acid are the most abundant bioactive compounds. The published epidemiological data demonstrating beneficial …

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  • CD40 deficiency in mice exacerbates obesity-induced ...

    2012-10-18 · CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance Chang-An Guo,1* Sophia Kogan,1* Shinya U. Amano,1 Mengxi Wang,1 Sezin Dagdeviren,1,2 Randall H. Friedline,1,2 Myriam Aouadi,1 Jason K. Kim,1,2 and Michael P. Czech1 1Program in Molecular Medicine, University of Massachusetts Medical School, …

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  • Comparison of Four Microwave Ablation Devices: An ...

    2013-7-1 · Microwave ablation of the liver: a description of lesion evolution over time and an investigation of the heat sink effect. Pathology 2011;43(7):725–731. Crossref, Medline, Google Scholar; 9 Lu DS, Raman SS, Limanond P et al.. Influence of large peritumoral vessels on outcome of radiofrequency ablation of liver tumors.

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  • Inhibition of Plasminogen Activator Inhibitor 1 Attenuates ...

    liVeR anD plasma CHemistRies Liver samples were homogenized in Dulbecco’s phosphate-buffered saline for hepatic lipid analy-sis (100 mg liver tissue/1 mL). Triglyceride levels were measured in liver homogenate using an Infinity spectrophotometric assay per the manufacturer’s pro-tocol (Thermo Electron Corporation, Melbourne, Australia).

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  • Influence of the heat irrigating effect of radiofrequency ...

    Coagulation necrosis occurred in liver tissue after RFA, the inflammatory response zone in the peripheral transition zone showed inflammatory cell infiltration and hyperemia changes, and gradually transitioned to normal liver tissue. The range of hepatic necrosis in group B was slightly wider than that in group A.

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  • Mechanical homeostasis of liver sinusoid is involved in ...

    2021-4-7 · Acute liver regeneration is induced by an increase in portal flow. a Schematic of the small orthotopic liver transplantation (s-OLT) model. The donor liver was harvested from 5-week-old Wistar rats and transplanted to 15-week-old Wistar rats. b Blood flow rate in the portal vein of donors and recipients (n = 3 for each age). Data are presented ...

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  • Liver function tests - Mayo Clinic

    2019-6-13 · Liver function tests are blood tests used to help diagnose and monitor liver disease or damage. The tests measure the levels of certain enzymes and proteins in your blood.

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  • CD36 deficiency ameliorates drug-induced acute liver ...

    2021-6-6 · CD36 deficiency reduced APAP-induced murine liver injury. WT mice were starved for 16 h and i.p. injected with APAP at 300 mg/kg. The expression of CD36 in the liver at specified time point after APAP treatment was determined by A q-PCR and B Western blotting. *p < 0.05, compared with 0 h; C Immunohistochemical staining of CD36 in the liver sections of mice treated …

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  • Effects of supplementation with main coffee components ...

    2021-4-10 · Non-alcoholic fatty liver disease (NAFLD) is much more frequent and more severe, including cirrhosis, hepatocellular carcinoma in patients with type 2 diabetes. Coffee is a complex beverage with hundreds of compounds whereas caffeine and chlorogenic acid are the most abundant bioactive compounds. The published epidemiological data demonstrating beneficial …

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  • α Protects against Hepatic Ischemia Reperfusion Injury by ...

    2020-11-9 · Research Article PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production Chaoqun Wang ,1 Zihao Li ,1 Baolei Zhao ,2 Yaohua Wu ,1 Yao Fu ,3 Kai Kang ,4 YaoLi ,4 LiqianDong ,1 XiaozhuangLi ,1 BaoZhang ,1 HuiboWu ,1 BenqiangShen,1 Yanan Xu ,1 Shangha Pan ,1 Hongchi Jiang ,1 Dawei Wang ,1 and …

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  • XATMEP | Methotrexate Oral Solution, 2.5 mg/mL

    Xatmep is the first and only FDA-approved Methotrexate oral solution. Methotrexate can cause the following severe or fatal adverse reactions. Monitor closely and modify dose or discontinue methotrexate as appropriate. Methotrexate can cause embryo-fetal toxicity, including fetal death.

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  • CD40 deficiency in mice exacerbates obesity-induced ...

    2012-10-18 · CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance Chang-An Guo,1* Sophia Kogan,1* Shinya U. Amano,1 Mengxi Wang,1 Sezin Dagdeviren,1,2 Randall H. Friedline,1,2 Myriam Aouadi,1 Jason K. Kim,1,2 and Michael P. Czech1 1Program in Molecular Medicine, University of Massachusetts Medical School, …

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  • Bromelain Confers Protection Against the Non-Alcoholic ...

    2020-5-18 · nutrients Article Bromelain Confers Protection Against the Non-Alcoholic Fatty Liver Disease in Male C57BL/6 Mice Po-An Hu 1, Chia-Hui Chen 1, Bei-Chia Guo 1, Yu Ru Kou 2 and Tzong-Shyuan Lee 1,* 1 Graduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan; [email protected] (P.-

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  • Hepatoprotective properties of Penthorum chinense Pursh ...

    2017-10-30 · Penthorum chinense Pursh (Penthoraceae, PCP), a well-known Miao ethnomedicine, has been traditionally used to treat several liver-related diseases, such as jaundice and viral hepatitis. The aims of the present study were to evaluate the probable properties of the aqueous extract of PCP on carbon tetrachloride (CCl4)—induced acute liver injury in mice.

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  • Early Growth Response Factor-1 Is Critical for Cholestatic ...

    2006-1-19 · The liver was then perfused with 40 ml of calcium- and magnesium-free HBSS supplemented with 1.5 mM calcium chloride, 5.5 mM glucose, penicillin-streptomycin, and 0.02 g of Type IV Collagenase (Sigma Chemical Company). The liver was removed, and the digested product was centrifuged at 50 × g for 2 min to pellet the hepatocytes. The hepatocytes ...

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  • Autophagy lessens ischemic liver injury by reducing ...

    2015-6-16 · Liver biopsy is considered the reference standard for fibrosis assessment and stage classification and also allows grading of steatosis, necrosis, and inflammatory activity. However, biopsy is invasive, with potential complications that can be severe in up to 1% of cases ( 4 , 5 ).

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  • Elastography Assessment of Liver Fibrosis: Society of ...

    2021-3-12 · BackgroundNecroptosis is a newly recognized form of programmed cell death with characteristics of both necrosis and apoptosis. The role of necroptosis in hepatic damage during sepsis is poorly understood. In this study, we investigated the occurrence of necroptosis in hepatic damage, and its contribution to hepatic damage in a piglet model of lipopolysaccharide (LPS) …

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  • Frontiers | Necroptosis Underlies Hepatic Damage in a ...

    2018-3-9 · BASIC AND TRANSLATIONAL—LIVER Tumor Necrosis Factor-producing T-regulatory Cells Are Associated With Severe Liver Injury in Patients With Acute Hepatitis A Yoon Seok Choi,1,2,* Min Kyung Jung,1,* Jeewon Lee,1 Seong Jin Choi,1 Sung Hoon Choi,3 Hyun Woong Lee,4 Jong-Joo Lee,5 Hyung Joon Kim,4 Sang Hoon Ahn,3 Dong Hyeon Lee,6

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  • Gastroenterology 2018;154:1047 BASIC AND

    2019-11-15 · the manufacturer’s instructions. NF-κB activity was assayed as previously described [21]. In brief, nuclear extracts from mouse liver tissues were prepared, and the binding of p65 to DNA was measured with the TransAM NF- κBp65 ELISA kit, according to manufacturer’s instructions. Quantitative real-time PCR

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  • Curcumin prevents high-fat diet-induced hepatic steatosis ...

    2016-12-8 · Orthotopic liver transplant (OLT) is the primary therapy for end-stage liver disease and acute liver failure. Ischemia/reperfusion injury (IRI) occurs as an inevitable consequence of the transplant process, beginning with organ procurement and preservation and followed by reperfusion of the donor organ with recipient blood during transplant (). ...

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  • JCI Insight - Early cytokine signatures of ischemia ...

    2021-6-29 · • Liver problems or worsening of liver problems including liver failure • Injection site problems, including skin damage (necrosis) • Low blood cell counts • Injury to small blood vessels, red blood cells and platelets (thrombotic microangiopathy), sometimes leading to death • Seizures Read the medication guide for a comprehensive

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  • DISEASE-MODIFYING THERAPIES FOR MS

    2011-1-11 · Only recently, several Hydroxycut products were retracted by the manufacturer following a warning posted by the FDA in May 2009 because of 23 reports of liver injury including cases with acute hepatic failure and subsequent liver transplantation (47-49). Hydroxycut preparations were sold as powder, capsules and tablets by conventional retailers ...

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  • Liver problems - Symptoms and causes - Mayo Clinic

    2020-10-13 · severity of liver fibrosis in patients with chronic viral hepatitis, best demonstrated in patients with hepatitis C. Impulse elastography 1D, ARFI, and SWI are more accurate in detecting cirrhosis than significant fibrosis. In recent years, several teams investigated the possibility of characterizing liver lesions on the

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  • Extracellular vesicles: Natural liver‐accumulating drug ...

    2020-12-9 · Liver injury was assessed based on haemorrhage, hepatocyte necrosis, inflammatory cell infiltration, cytoplasm vacuolization and nuclear condensation (Yan et al., 2017). These scoring procedures were scored by two blinded observers.

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  • Review of liver injury associated with dietary supplements ...

    2011-1-11 · Only recently, several Hydroxycut products were retracted by the manufacturer following a warning posted by the FDA in May 2009 because of 23 reports of liver injury including cases with acute hepatic failure and subsequent liver transplantation (47-49). Hydroxycut preparations were sold as powder, capsules and tablets by conventional retailers ...

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  • Fulminant hepatitis B reactivation leading to liver ...

    2015-7-28 · f High-magnification view of liver explant specimen shows confluent necrosis and bridging necrosis with bile ductular reaction and cholestasis Full size image At week 11 of a planned 12-week course, she was found to have ALT 2263U/L, AST 2870U/L, total bilirubin of 9.1mg/dL and an international normalized ratio (INR) of 1.9.

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  • Enbrel® (etanercept) | Official Patient Site

    Enbrel® (etanercept) is a prescription medication used to treat five chronic diseases including moderate to severe rheumatoid arthritis (RA), psoriatic arthritis (PsA), moderate to severe plaque psoriasis (PsO), ankylosing spondylitis (AS), and moderate to severe polyarticular juvenile idiopathic arthritis (JIA). Please see Indications and Important Safety Information.

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  • Therapeutic liver repopulation by transient acetaminophen ...

    2021-6-9 · Gene therapy vectors that integrate into the genome (as opposed to remaining episomal) promise sustained therapeutic effects for monogenic liver diseases in theory but typically do not integrate into sufficient numbers of hepatocytes to achieve therapeutic effects in practice. To increase therapeutic yields, Vonada et al . added a short hairpin RNA targeting Cypor, a …

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  • Radiofrequency Ablation of the Liver : American Journal of ...

    2019-9-15 · Radiofrequency ablation of the liver is considered safe, with an extremely low major complication rate observed by multiple groups. More serious complications have been reported in the literature. Rossi et al. described capsular necrosis, and Solbiati et al. [57, 59] reported

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  • ACG Clinical Guideline: The Diagnosis and Management of ...

    2021-7-6 · Despite its low incidence in the general population, gastroenterologists must always consider the possibility of DILI in patients with unexplained acute and chronic liver injury, as well as when prescribing certain gastrointestinal medications (e.g., azathioprine, anti-tumor necrosis factor agents, sulfonamides) (7, 8). Many herbal and dietary ...

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  • ACG Clinical Guideline: Diagnosis and Management of ...

    Imatinib is a specific tyrosine kinase inhibitor which has been approved for the treatment of Philadelphia chromosome-positive chronic myeloid leukaemia and c-KIT (CD117)-positive gastrointestinal stromal tumours. It has been associated with hepatotoxicity ranging from abnormal liver function tests to acute liver failure along with chronic hepatitis B reactivation.

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  • Necrosulfonamide | ≥99%(HPLC) | Selleck | Mixed Lineage ...

    2021-6-9 · Gene therapy vectors that integrate into the genome (as opposed to remaining episomal) promise sustained therapeutic effects for monogenic liver diseases in theory but typically do not integrate into sufficient numbers of hepatocytes to achieve therapeutic effects in practice. To increase therapeutic yields, Vonada et al . added a short hairpin RNA targeting Cypor, a …

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  • Therapeutic liver repopulation by transient acetaminophen ...

    2015-7-28 · f High-magnification view of liver explant specimen shows confluent necrosis and bridging necrosis with bile ductular reaction and cholestasis Full size image At week 11 of a planned 12-week course, she was found to have ALT 2263U/L, AST 2870U/L, total bilirubin of 9.1mg/dL and an international normalized ratio (INR) of 1.9.

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  • Fulminant hepatitis B reactivation leading to liver ...

    2005-3-28 · Liver histology confirmed the sALT estimation of liver damage. Severe sinusoidal congestion and hepatocellular necrosis was present in liver tissue from mice that were treated with control IgG, whereas minimal damage was noted in samples from anti-HMGB1–treated mice (Fig. 1 …

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  • The nuclear factor HMGB1 mediates hepatic injury after ...

    2013-1-12 · Based on these results, liver tissue bioenergetics is increased 3 hr after ConA exposure. This effect is driven by the pathogenesis of the disease, in which IFN-γ and other cytokines contribute to. Subsequent declines in liver bioenergetics appear to be a result of necrosis and active caspases targeting the mitochondria within hepatocytes.

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  • Derangements of liver tissue bioenergetics in Concanavalin ...

    2020-7-2 · Macrophages play a significant role in liver disease development and progression. The macrophage activation marker soluble (s)CD163 is associated with severity and prognosis in a number of different acute and chronic liver diseases but has been only sparsely examined in Wilson’s disease (WD). We investigated sCD163 levels in patients with acute and chronic WD and …

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  • ACG Clinical Guideline: Diagnosis and Management of ...

    2015-10-1 · Cannabidiol (CBD) is a component of cannabis, which does not cause the typical marijuana-type effects, but has a high potential for use in several therapeutic areas. In contrast to Δ9-tetrahydrocannabinol (Δ9-THC), it binds very weakly to the CB1 and CB2 cannabinoid receptors. It has potent activity in both in vitro and in vivo anti-inflammatory assays. Thus, it lowers the …

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  • The macrophage activation marker soluble CD163 is

    2015-4-10 · The imaging degrees of fatty liver patients are shown in Table 2. There were signifi-cant differences in cases with mild, moderate, and severe fatty liver between the NAFLD and complicated groups (P < 0.05). Liver/spleen CT ratio, ALT, TG, HOMA-IR, APN, and TNF-a levels in fatty liver patients with different imaging degrees are shown in Table 3.

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  • iRhom2 inhibits bile duct obstruction–induced liver ...

    2019-9-15 · Radiofrequency ablation of the liver is considered safe, with an extremely low major complication rate observed by multiple groups. More serious complications have been reported in the literature. Rossi et al. described capsular necrosis, and Solbiati et al. [57, 59] reported

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  • ACG Clinical Guideline: Diagnosis and Management of ...

    Imatinib is a specific tyrosine kinase inhibitor which has been approved for the treatment of Philadelphia chromosome-positive chronic myeloid leukaemia and c-KIT (CD117)-positive gastrointestinal stromal tumours. It has been associated with hepatotoxicity ranging from abnormal liver function tests to acute liver failure along with chronic hepatitis B reactivation.

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  • Shedding of the tumor necrosis factor (TNF) receptor from ...

    2021-7-13 · y is a survival mechanism for eukaryote to recycle intracellular nutrients and maintain energy homeostasis. We hypothesize that autophagy plays a beneficial role in the pathogenesis of organ failure during sepsis. A rat model of cecal ligation and puncture (CLP) that simulate peritonitis-induced sepsis was used, and indicators for liver dysfunction, serum glutamic …

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  • Radiofrequency Ablation of the Liver : American Journal of ...

    2016-1-22 · Licorice is the root of Glycyrriza uralensis Fischer, Glycyrrhiza glabra Linné or Glycyrrhiza inflata Batalin (Fabaceae), which has been used as traditional medicine since ancient times. In particular, licorice was used as a medical raw material for multiple purposes such as antidote, antitussive expectorant, relaxant, to relieve pain that occurs because of a sudden …

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  • Imatinib and liver toxicity | BMJ Case Reports

    2 haifiT, eal unher ancer 20219:e002131 doi:101136/itc-2020-002131 Open access factor receptor superfamily of receptors (TNFRSF), which includes CD27, 4-1BB (CD137), OX40 (CD134) and GITR (CD357) have been targeted using agonist antibodies. 104- 1BB is a potent stimulator of T cells and natural killer (NK) cellspurchased from Gempharmatech (Jiangsu, China).

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  • Suppression of Autophagy in Rat Liver at Late Stage of ...

    2012-3-1 · Non-alcoholic fatty liver disease (NAFLD) is a common disease associated to obesity and increased visceral fat. This condition has the potential to develop hepatic fibrosis and end-stage liver disease, and is associated with several non-hepatic related complications [].Liver fibrosis is a complex event that could be conceptually divided in three phases: initiation, perpetuation and …

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  • Hepatoprotective effect of licorice, the root of ...

    Prolia® is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. Prolia® is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines (such as prednisone) for at least six months and are at high risk for fracture.

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  • EIAab: The Top Notch Elisa Kit Manufacturers | Find Out ...

    EIAab is one of the leading international elisa kit manufaturers and supplier. Being one of the most promising elisa sets supplier, now you can buy various high quality elisa kit …

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  • A lung/liver-on-a-chip platform for acute and chronic ...

    2018-11-21 · The merging of three-dimensional in vitro models with multi-organ-on-a-chip (MOC) technology has taken in vitro assessment of chemicals to an unprecedented level. By connecting multiple organotypic models, MOC allows for the crosstalk between different organs to be studied to evaluate a compound's safety and Lab on a Chip Recent Open Access Articles Organ-, body- …

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  • Molecular Mechanisms of Liver Carcinogenesis in the Mdr2 ...

    Results Liver Tumor Development. We have previously described that livers of Mdr2-KO mice at 12 months of age were characterized by disrupted lobular structure and appearance of dysplastic nodules, some of them being steatotic ().The number and size of visible liver tumors in Mdr2-KO mice increased gradually with age.

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  • Shedding of the tumor necrosis factor (TNF) receptor from ...

    2014-8-3 · Experimental biomarkers. Only the serum samples (baseline and peak) from subjects who experienced elevations in serum ALT exceeding 3 × ULN were archived and assayed for experimental biomarker analysis (Figure 3).The mean serum level of the liver-specific miRNA-122 [] was elevated 22.4-fold over baseline (P < 0.05); mean levels of necrosis biomarkers SDH and …

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  • Benign elevations in serum aminotransferases and ...

    2 haifiT, eal unher ancer 20219:e002131 doi:101136/itc-2020-002131 Open access factor receptor superfamily of receptors (TNFRSF), which includes CD27, 4-1BB (CD137), OX40 (CD134) and GITR (CD357) have been targeted using agonist antibodies. 104- 1BB is a potent stimulator of T cells and natural killer (NK) cellspurchased from Gempharmatech (Jiangsu, China).

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  • Generation of a safe and efficacious llama single-domain ...

    2021-6-6 · contributes to cell necrosis. Recent studies indicate that sterile inammation and innate immune cells may play important roles in damage-induced hepatocyte regenera-tion and liver repair (Woolbright and Jaeschke 2017). e cell necrosis leads to the release of damage-associated molecular patterns (DAMPs) including HMGB1 protein,

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  • Treatment with etanercept of autoimmune hepatitis ...

    2012-11-7 · In liver, amiodarone concentrations are 10–20 times higher than in plasma (Wyss et al., 1990), suggesting that the results of this study are clinically relevant. This assumption is supported by the observation that in 104 patients treated with amiodarone and followed prospectively, 25 developed an increase in serum transaminases and 3 out of ...

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  • CD36 deficiency ameliorates drug-induced acute liver ...

    drome.2 Liver steatosis is often considered a benign con-dition, but it can progress to nonalcoholic steatohepatitis (NASH), which may be a precursor to more severe liver diseases such as cirrhosis and hepatocellular carcinoma.3 NASH is a common liver disease in the United States, and its prevalence is on the rise worldwide. NASH is

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