Pulsatilla camphor | CAS:90921-11-2 | Triterpenoids |
The strong hemolytic toxicity of pulsatilla saponin D (1, HD50 6.3 muM) has hampered its clinical development as an injectable anticancer agent. To combat this challenge, 17 new derivatives of 1 with ring C, C-28, or C-3 modifications were synthesized and evaluated for cytotoxicity against several selected human tumor lines, as well as for hemolytic toxicity against rabbit erythrocytes.
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